Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA
-
Abdollah Jafarzadeh
,
Maryam Nemati
,
Mohammad-Taghi Rezayati
,
Hossain Khoramdel
,
Mansooreh Nabizadeh
,
Gholamhossain Hassanshahi
,
Hamid Abdollahi
Abstract
Background and Objectives: Alterations in CXCL10 (a Th1 chemokine) expression have been associated with various diseases. The aim of this study was to evaluate the serum CXCL10 levels in H. pylori-infected patients with peptic ulcer (PU), H. pylori-infected asymptomatic (AS) subjects and healthy H. pylori-negative subjects, and also to determine its association with bacterial virulence factor cytotoxin-associated gene A (CagA).
Materials and Methods: Serum samples from 90 H. pylori infected patients with PU (70 were anti-CagA+, 20 were anti- CagA-), 65 AS carriers (40 were anti-CagA+, 25 were anti-CagA-) and 30 healthy H. pylori-negative subjects (as a control group) were tested for concentrations of CXCL10 by using the ELISA method.
Results: The mean serum levels of CXCL10 in PU patients (96.64 ± 20.85 pg/mL) were significantly lower than those observed in AS subjects (162.16 ± 53.31 pg/mL, P < 0.01) and the control group (193.93 ± 42.14 pg/mL, P < 0.02). In the PU group, the serum levels of CXCL10 in anti-CagA+ subjects was significantly higher in comparison to anti-CagA- patients (P < 0.04).
Conclusion: These results showed that the mean concentrations of CXCL10 in H. pylori-infected-PU patients was lower than AS carriers and control group. In the PU group, the serum levels of CXCL10 were associated with bacterial factor CagA.
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| Issue | Vol 5 No 1 (2013) | |
| Section | Articles | |
| Keywords | ||
| Anti-CagA Chemokine CXCL10 Helicobacter pylori Iran Kerman Province Peptic Ulcer Rafsanjan | ||
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