Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 5 1 2013 03 15 28 35 EN Abdollah Jafarzadeh Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Immunology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Maryam Nemati Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Mohammad-Taghi Rezayati Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Hossain Khoramdel Immunology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Mansooreh Nabizadeh Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Gholamhossain Hassanshahi Immunology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Hamid Abdollahi Department of Microbiology and Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran. 2015 10 16 Background and Objectives: Alterations in CXCL10 (a Th1 chemokine) expression have been associated with various diseases. The aim of this study was to evaluate the serum CXCL10 levels in H. pylori-infected patients with peptic ulcer (PU), H. pylori-infected asymptomatic (AS) subjects and healthy H. pylori-negative subjects, and also to determine its association with bacterial virulence factor cytotoxin-associated gene A (CagA). Materials and Methods: Serum samples from 90 H. pylori infected patients with PU (70 were anti-CagA+, 20 were anti- CagA-), 65 AS carriers (40 were anti-CagA+, 25 were anti-CagA-) and 30 healthy H. pylori-negative subjects (as a control group) were tested for concentrations of CXCL10 by using the ELISA method. Results: The mean serum levels of CXCL10 in PU patients (96.64 ± 20.85 pg/mL) were significantly lower than those observed in AS subjects (162.16 ± 53.31 pg/mL, P < 0.01) and the control group (193.93 ± 42.14 pg/mL, P < 0.02). In the PU group, the serum levels of CXCL10 in anti-CagA+ subjects was significantly higher in comparison to anti-CagA- patients (P < 0.04). Conclusion: These results showed that the mean concentrations of CXCL10 in H. pylori-infected-PU patients was lower than AS carriers and control group. In the PU group, the serum levels of CXCL10 were associated with bacterial factor CagA. https://ijm.tums.ac.ir/index.php/ijm/article/view/640 https://ijm.tums.ac.ir/index.php/ijm/article/download/640/413