Application of Saccharomyces boulardii in feed to improve health, wellness and productivity
Abstract
One of the main pillars of human health depends on healthy nutrition. Chicken makes up a significant part of human nutrition particularly in societies experiencing economic inflation and severe disruptions to people's livelihoods. So livestock and poultry pose a crucial impact on food safety and immunity. Probiotics have acquired worldwide acceptance as a healthy ingredient for usage as a potential feed supplement to reduce food-borne diseases and confirm food hygiene from farm to fork. Feed additives containing live yeast, e.g. Saccharomyces boulardii, and yeast derivative products can increase feed intake and intestinal health, and improve productivity. This probiotic, non-pathogenic yeast possesses several health-beneficial properties for poultry and livestock. However, it was previously believed that yeast did not have an effective probiotic effect in chicken and poultry. In this review, the advantages of using Saccharomyces boulardii has been introduced as a probiotic for poultry and livestock. This comprehensive analysis explores the multifaceted applications of probiotics in animal feed from health and AMR perspectives, examining their mechanisms of action, benefits, and potential to transform sustainable animal production practices.
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5. Rajput IR, Li LY, Xin X, Wu BB, Juan ZL, Cui ZW, et al. Effect of Saccharomyces boulardii and Bacillus subtilis B10 on intestinal ultrastructure modulation and mucosal immunity development mechanism in broiler chickens. Poult Sci 2013; 92: 956–965.
6. Moslehi-Jenabian S, Pedersen LL, Jespersen L. Beneficial effects of probiotic and food borne yeasts on human health. Nutrients 2010; 2: 449-473.
7. Sun Y, Rajput IR, Arain MA, Li Y, Baloch DM. Oral administration of Saccharomyces boulardii alters duodenal morphology, enzymatic activity, and cytokine production response in broiler chickens. Anim Sci J 2017; 88: 1204-1211.
8. Naseeb S, James SA, Alsammar H, Michaels CJ, Gini B, Nueno-Palop C, et al. Saccharomyces jurei sp. nov., isolation and genetic identification of a novel yeast species from Quercus robur. Int J Syst Evol Microbiol 2017; 67: 2046-2052.
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11. Ansari F, Alian Samakkhah S, Bahadori A, Jafari SM, Ziaee M, Khodayari MT, et al. Health-promoting properties of Saccharomyces cerevisiae var. boulardii as a probiotic; characteristics, isolation, and applications in dairy products. Crit Rev Food Sci Nutr 2023; 63: 457-485.
12. Abid R, Waseem H, Ali J, Ghazanfar S, Muhammad Ali G, Elasbali AM, et al. Probiotic yeast Saccharomyces: Back to nature to improve human health. J Fungi (Basel) 2022; 8: 444.
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15. Redweik GAJ, Jochum J, Mellata M. Live bacterial prophylactics in modern poultry. Front Vet Sci 2020; 7: 592312.
16. Srednicka P, Juszczuk-Kubiak E, Wójcicki M, Akimowicz M, Roszko M. Probiotics as a biological detoxification tool of food chemical contamination: A review. Food Chem Toxicol 2021; 153: 112306.
17. Pourabedin M, Xu Z, Baurhoo B, Chevaux E, Zhao X. Effects of mannan oligosaccharide and virginiamycin on the cecal microbial community and intestinal morphology of chickens raised under suboptimal conditions. Can J Microbiol 2014; 60: 255-266.
18. Jiang Z, Wei S, Wang Z, Zhu C, Hu S, Zheng C, et al. Effects of different forms of yeast Saccharomyces cerevisiae on growth performance, intestinal development, and systemic immunity in earlyweaned piglets. J Anim Sci Biotechnol 2015; 6: 47.
19. Vohra A, Syal P, Madan A. Probiotic yeasts in livestock sector. Anim Feed Sci Technol 2016; 219: 31-47.
20. Zaworski EM, Shriver-munsch CM, Fadden NA, Sanchez WK, Yoon I, Bobe G. Effects of feeding various dosages of Saccharomyces cerevisiae fermentation product in transition dairy cows. J Dairy Sci 2014; 97: 3081-3098.
21. Magalhães VJA, Susca F, Lima FS, Branco AF, Yoon I, Santos JE. Effect of feeding yeast culture on performance, health, and immunocompetence of dairy calves. J Dairy Sci 2008; 91: 1497-1509.
22. Zhang W, Bao C, Wang J, Zang J, Cao Y. Administration of Saccharomyces boulardii mafic-1701 improves feed conversion ratio, promotes antioxidant capacity, alleviates intestinal inflammation and modulates gut microbiota in weaned piglets. J Anim Sci Biotechnol 2020; 11: 112.
23. Wang C, Li W, Wang H, Ma Y, Zhao X, Zhang X, et al. Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-alpha and IL-6 levels and functions and by rebalancing intestinal microbiota. BMC Microbiol 2019; 19: 246.
24. Alugongo GM , Xiao J, Wu Z, Li S, Wang Y, Cao Z. Review: Utilization of yeast of Saccharomyces cerevisiae origin in artificially raised calves. J Anim Sci Biotechnol 2017; 8: 34.
25. Chaudhary SS, Singh VK, Upadhyay RC, Puri G, Odedara AB, Patel PA. Evaluation of physiological and biochemical responses in different seasons in Surti buffaloes. Vet World 2015; 8: 727-731.
26. Lee JS, Kacem N, Kim WS, Peng DQ, Kim YJ, Joung YG, et al. Effect of Saccharomyces boulardii supplementation on performance and physiological traits of Holstein calves under heat stress conditions. Animals (Basel) 2019; 9: 510.
27. Pinos-Rodríguez J, Robinson PH, Ortega ME, Berry SL, Mendoza G, Barcena R. Performance and rumen fermentation of dairy calves supplemented with Saccharomyces cerevisiae 1077 or Saccharomyces boulardii 1079. Anim Feed Sci Technol 2008; 140: 223-232.
28. Philpot CS (2015). Saccharomyces boulardii as an enteric health promoter in broiler chickens. Poultry science undergraduate honors theses retrieved from https://scholarworks.uark.edu/poscuht/2
29. Javadi A, Mirzaei H, Safarmashaei S, Vahdatpour S. Effects of probiotic (live and inactive Saccharomyces cerevisiae) on meat and intestinal microbial properties of Japanese quails. Afr J Biotechnol 2012; 11: 12083-12087.
30. Higgins SE, Higgins JP, Wolfenden AD, Henderson SN, Torres-Rodriguez A, Tellez G, et al. Evaluation of a Lactobacillus-based probiotic culture for the reduction of Salmonella enteritidis in neonatal broiler chicks. Poult Sci 2008; 87: 27-31.
31. Massacci FR, Lovito C, Tofani S, Tentellini M, Genovese DA, De Leo AAP, et al. Dietary Saccharomyces cerevisiae boulardii CNCM I-1079 positively affects performance and intestinal ecosystem in broilers during a Campylobacter jejuni infection. Microorganisms 2019; 7: 596.
32. Murzyn A, Krasowska A, Stefanowicz P, Dziadkowiec D, £ukaszewicz M. Capric acid secreted by S. boulardii inhibits C. albicans filamentous growth, adhesion and biofilm formation. PLoS One 2010; 5(8): e12050.
33. Abudabos AM, Alhouri HAA, Alhidary IA, Nassan MA, Swelum AA. Ameliorative effect of Bacillus subtilis, Saccharomyces boulardii, oregano, and calcium montmorillonite on growth, intestinal histology, and blood metabolites on Salmonella-infected broiler chicken. Environ Sci Pollut Res Int 2019; 26: 16274-16278.
34. Spring P, Wenk C, Dawson KA, Newman KE. The effects of dietary mannan oligosaccharides on cecal parameters and the concentrations of enteric bacteria in the ceca of Salmonella challenge broiler chicks. Poult Sci 2000; 79: 205-211.
35. Gao F, Jiang Y, Zhou GH, Han ZK. The effects of xylanase supplementation on performance, characteristics of the gastrointestinal tract, blood parameters and gut microflora in broilers fed on wheat-based diets. Anim Feed Sci Technol 2008; 142: 173-184.
36. Al-Khalaifah HS. Benefits of probiotics and/or prebiotics for antibiotic-reduced poultry. Poult Sci 2018; 97: 3807-3815.
37. Ogbuewu IP, Mabelebele M, Sebola NA, Mbajiorgu C. Bacillus probiotics as alternatives to in-feed antibiotics and its influence on growth, serum chemistry, antioxidant status, intestinal histomorphology, and lesion scores in disease-challenged broiler chickens. Front Vet Sci 2022; 9: 876725.
38. Walter J, Maldonado-Gomez MX, Martinez I. To engraft or not to engraft: an ecological framework for gut microbiome modulation with live microbes. Curr Opin Biotechnol 2018; 49: 129-139.
39. Chae J-B, Schoofs AD, McGill JL. Beneficial effects of Saccharomyces cerevisiae fermentation postbiotic products on calf and cow health and plausible mechanisms of action. Front Anim Sci 2024; 5: 10.3389/fanim.2024.1491970.
40. Fonty G, Chaucheyras-Durand F. Effects and modes of action of live yeasts in the rumen. Biologia 2006; 61: 741-750.
41. Capitán-Cañadas F (2014). New insights into the mechanisms of prebiotics and microbiota on intestinal defense. Universidad de Granada: Granada, Spain.
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| Files | ||
| Issue | Vol 17 No 5 (2025) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijm.v17i5.19876 | |
| Keywords | ||
| Probiotics Yeasts Saccharomyces boulardii Chickens Meat Health | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Zoghi A, Khosravi-Darani K. Application of Saccharomyces boulardii in feed to improve health, wellness and productivity. Iran J Microbiol. 2025;17(5):682-694.
