Seroprevalence of Helicobacter pylori in a population of 15 to 35 years old in Mashhad
-
Mahdieh Khoshakhlagh
,
Mohammadreza Tarahomi
,
Fatemeh Asgharian
,
Arghavan Kamali
,
Safoora Sa'd Abadi
,
Kimia Jafarpour
,
Samaneh Abolbashari
,
Mojtaba Meshkat
,
Aida Gholoobi
Abstract
Background and Objectives: Helicobacter pylori (H. pylori) is a bacterium involved in gastrointestinal disorders with a high prevalence in Iran. We have determined the seroprevalence of H. pylori in the young adult population of Mashhad city for the first time.
Materials and Methods: We carried out a cross-sectional study on 933 individuals between the ages of 15 and 35 in Mashhad. The serum level of IgG, IgM, and IgA H. pylori antibodies was determined using enzyme linked immunosorbent assay (ELISA) method.
Results: The average age of the participants including 290 (31.0%) male and 643 (68.9%) female cases was 25.47 ± 5.76. H. pylori IgG was seropositive in 365 (39.1%) of subjects. Occupation (p=0.002), body mass index (p=0.002), marital status (p<0.0001), and age (p<0.007) were meaningfully related to H. pylori IgG seropositivity. Other factors such as sex, educational attainment, history of chronic diseases, and smoking cigarette had no significant relationship with the presence of H. pylori antibodies.
Conclusion: The seroprevalence of H. pylori IgG antibodies in Mashhad's 15 to 35 years old citizens was determined 39.1%. We suggest further studies with larger sample sizes and different age groups as the target population.
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28. Mansori K, Dehghanbanadaki H, Naderpour S, Rashti R, Moghaddam AB, Moradi Y. A systematic review and meta-analysis of the prevalence of Helicobacter pylori in patients with diabetes. Diabetes Metab Syndr 2020; 14: 601-607.
29. Huang M, Zhu L, Jin Y, Fang Z, Chen Y, Yao Y. Association between Helicobacter pylori infection and systemic arterial Hypertension: A Meta-Analysis. Arq Bras Cardiol 2021; 117: 626-636.
30. Seo KI, Heo JJ, Kim SE, Park SJ, Park MI, Moon W, et al. Sex differences between Helicobacter pylori infection and cholesterol levels in an adult health checkup program. Helicobacter 2020; 25(4): e12704.
31. Zaidi SF. Helicobacter pylori associated Asian enigma: Does diet deserve distinction? World J Gastrointest Oncol 2016; 8: 341-350.
32. Hojati SA, Kokabpeyk S, Yaghoubi S, Joukar F, Asgharnezhad M, Mansour-Ghanaei F. Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors. BMC Gastroenterol 2021; 21: 355.
2. Meshkat M, Behjati Y, Bakhshi M, Meshkat Z, Yazdan Mehr M, Boostani R, et al. Serum evaluation of Helicobacter pylori in patients with multiple sclerosis. Arch Neurosci 2023; 10(3): e133607.
3. Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G. Diagnosis of Helicobacter pylori: what should be the gold standard? World J Gastroenterol 2014; 20: 12847-12859.
4. Gravina AG, Zagari RM, De Musis C, Romano L, Loguercio C, Romano M. Helicobacter pylori and extragastric diseases: A review. World J Gastroenterol 2018; 24: 3204-3221.
5. Sayehmiri F, Kiani F, Sayehmiri K, Soroush S, Asadollahi K, Alikhani MY, et al. Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis. J Infect Dev Ctries 2015; 9: 686-696.
6. Feldman M, Friedman LS, Brandt LJ (2016). Sleisenger and Fordtran's gastrointestinal and liver disease : pathophysiology/diagnosis/ management: Tenth edition. Philadelphia. Saunders.
7. Al-Zubaidi AM, Alzobydi AH, Alsareii SA, Al-Shahrani A, Alzaman N, Kassim S. Body mass index and Helicobacter pylori among obese and non-obese patients in najran, Saudi Arabia: a case-control study. Int J Environ Res Public Health 2018; 15: 2586.
8. Hamrah MH, Hamrah MS, Hassan Hamrah M, Kanda M, Hamrah AE, Dahi AE, et al. Prevalence of Helicobacter pylori infection in dyspeptic patients in andkhoy afghanistan. Asian Pac J Cancer Prev 2017; 18: 3123-3127.
9. Sgambato D, Visciola G, Ferrante E, Miranda A, Romano L, Tuccillo C, et al. Prevalence of Helicobacter pylori infection in sexual partners of H. pylori-infected subjects: Role of gastroesophageal reflux. United European Gastroenterol J 2018; 6: 1470-1476.
10. Ertem D, Harmanci H, Pehlivanoğlu E. Helicobacter pylori infection in Turkish preschool and school children: role of socioeconomic factors and breast feeding. Turk J Pediatr 2003; 45: 114-122.
11. Shokrzadeh L, Baghaei K, Yamaoka Y, Shiota S, Mirsattari D, Porhoseingholi A, et al. Prevalence of Helicobacter pylori infection in dyspeptic patients in Iran. Gastroenterol Insights 2012; 4(1): e8.
12. Ashtari S, Pourhoseingholi MA, Molaei M, Taslimi H, Zali MR. The prevalence of Helicobacter pylori is decreasing in Iranian patients. Gastroenterol Hepatol Bed Bench 2015; 8(Suppl 1): S23-S29.
13. Shakeri MT, Nomani H, Ghayour Mobarhan M, Sima HR, Gerayli S, Shahbazi S, et al. The prevalence of hepatitis C virus in mashhad, iran: a population-based study. Hepat Mon 2013; 13(3): e7723.
14. Zhu Y, Zhou X, Wu J, Su J, Zhang G. Risk factors and prevalence of Helicobacter pylori infection in persistent high incidence area of gastric carcinoma in yangzhong city. Gastroenterol Res Pract 2014; 2014: 481365.
15. Taylor CS, McMahon MV, Ward ZJ, Alarid-Escudero F, Camargo MC, Laszkowska M, et al. (2024). Birth cohort and age-specific trends in global Helicobacter pylori seroprevalence: a scoping review. The Lancet Regional Health–Americas.
16. Moosazadeh M, Lankarani KB, Afshari M. Meta-analysis of the prevalence of Helicobacter pylori infection among children and adults of Iran. Int J Prev Med 2016; 7: 48.
17. Jafarzadeh A, Ahmedi-Kahanali J, Bahrami M, Taghipour Z. Seroprevalence of anti-Helicobacter pylori and anti-CagA antibodies among healthy children according to age, sex, ABO blood groups and Rh status in south-east of Iran. Turk J Gastroenterol 2007; 18: 165-171.
18. Kassid OM, Khalaf Raheem A, Shamikh Hassan A. Prevalence and risk factors of Helicobacter pylori infection in Misan, Iraq: A cross-sectional screening study using stool Antigen Test. J Med Chem Sci 2022; 5: 1177-1182.
19. Borka Balas R, Meliț LE, Mărginean CO. Worldwide prevalence and risk factors of Helicobacter pylori infection in children. Children (Basel) 2022; 9: 1359.
20. Hadji M, Mortazavi M, Saberi S, Esmaieli M, Amini N, Akrami R, et al. Helicobacter pylori acquisition rates and the associated risk factors amongst newlywed couples; a prospective cohort study in Tehran, Iran. Microbes Infect 2022; 24: 104974.
21. Brenner H, Weyermann M, Rothenbacher D. Clustering of Helicobacter pylori infection in couples: differences between high- and low-prevalence population groups. Ann Epidemiol 2006; 16: 516-520.
22. Hojati SA, Kokabpeyk S, Yaghoubi S, Joukar F, Asgharnezhad M, Mansour-Ghanaei F. Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors. BMC Gastroenterol 2021; 21: 355.
23. Lender N, Talley NJ, Enck P, Haag S, Zipfel S, Morrison M, et al. Review article: Associations between Helicobacter pylori and obesity--an ecological study. Aliment Pharmacol Ther 2014; 40: 24-31.
24. Baradaran A, Dehghanbanadaki H, Naderpour S, Pirkashani LM, Rajabi A, Rashti R, et al. The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case-control studies. Clin Diabetes Endocrinol 2021; 7: 15.
25. Talebi-Taher M, Mashayekhi M, Hashemi MH, Bahrani V. Helicobacter pylori in diabetic and non-diabetic patients with dyspepsia. Acta Med Iran 2012; 50: 315-318.
26. Bener A, Micallef R, Afifi M, Derbala M, Al-Mulla HM, Usmani MA. Association between type 2 diabetes mellitus and Helicobacter pylori infection. Turk J Gastroenterol 2007; 18: 225-229.
27. Gulcelik NE, Kaya E, Demirbas B, Culha C, Koc G, Ozkaya M, et al. Helicobacter pylori prevalence in diabetic patients and its relationship with dyspepsia and autonomic neuropathy. J Endocrinol Invest 2005; 28: 214-217.
28. Mansori K, Dehghanbanadaki H, Naderpour S, Rashti R, Moghaddam AB, Moradi Y. A systematic review and meta-analysis of the prevalence of Helicobacter pylori in patients with diabetes. Diabetes Metab Syndr 2020; 14: 601-607.
29. Huang M, Zhu L, Jin Y, Fang Z, Chen Y, Yao Y. Association between Helicobacter pylori infection and systemic arterial Hypertension: A Meta-Analysis. Arq Bras Cardiol 2021; 117: 626-636.
30. Seo KI, Heo JJ, Kim SE, Park SJ, Park MI, Moon W, et al. Sex differences between Helicobacter pylori infection and cholesterol levels in an adult health checkup program. Helicobacter 2020; 25(4): e12704.
31. Zaidi SF. Helicobacter pylori associated Asian enigma: Does diet deserve distinction? World J Gastrointest Oncol 2016; 8: 341-350.
32. Hojati SA, Kokabpeyk S, Yaghoubi S, Joukar F, Asgharnezhad M, Mansour-Ghanaei F. Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors. BMC Gastroenterol 2021; 21: 355.
| Files | ||
| Issue | Vol 16 No 6 (2024) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijm.v16i6.17255 | |
| Keywords | ||
| Prevalence; Seroepidemiologic studies; Helicobacter pylori; Iran; Young adult | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Khoshakhlagh M, Tarahomi M, Asgharian F, Kamali A, Sa’d Abadi S, Jafarpour K, Abolbashari S, Meshkat M, Gholoobi A. Seroprevalence of Helicobacter pylori in a population of 15 to 35 years old in Mashhad. Iran J Microbiol. 2024;16(6):773-779.
