Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 16 6 2024 12 08 773 779 Mahdieh Khoshakhlagh Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammadreza Tarahomi Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Fatemeh Asgharian Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Arghavan Kamali Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Safoora Sa'd Abadi Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Kimia Jafarpour Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Samaneh Abolbashari Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mojtaba Meshkat Department of Community Medicine, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran Aida Gholoobi Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2023 08 06 2024 10 09 Background and Objectives: Helicobacter pylori (H. pylori) is a bacterium involved in gastrointestinal disorders with a high prevalence in Iran. We have determined the seroprevalence of H. pylori in the young adult population of Mashhad city for the first time. Materials and Methods: We carried out a cross-sectional study on 933 individuals between the ages of 15 and 35 in Mashhad. The serum level of IgG, IgM, and IgA H. pylori antibodies was determined using enzyme linked immunosorbent assay (ELISA) method. Results: The average age of the participants including 290 (31.0%) male and 643 (68.9%) female cases was 25.47 ± 5.76. H. pylori IgG was seropositive in 365 (39.1%) of subjects. Occupation (p=0.002), body mass index (p=0.002), marital status (p<0.0001), and age (p<0.007) were meaningfully related to H. pylori IgG seropositivity. Other factors such as sex, educational attainment, history of chronic diseases, and smoking cigarette had no significant relationship with the presence of H. pylori antibodies. Conclusion: The seroprevalence of H. pylori IgG antibodies in Mashhad's 15 to 35 years old citizens was determined 39.1%. We suggest further studies with larger sample sizes and different age groups as the target population. https://ijm.tums.ac.ir/index.php/ijm/article/view/4347 https://ijm.tums.ac.ir/index.php/ijm/article/download/4347/1728