Mycoplasma genitalium and Mycoplasma hominis infection in south Korea during 2018-2020
Abstract
Background and Objectives: Sexually transmitted infections (STIs) can remain undetected and untreated; therefore, rapid diagnosis and treatment of STIs are important. Mycoplasma genitalium (MG), Mycoplasma hominis (MH), and Ureaplasma urealyticum are sexually transmitted pathogens that cause asymptomatic, organ-specific, and chronic infections, thereby posing a threat to community health. Therefore, we investigated the epidemiological trends of MG and MH infections in South Korea for rapid diagnosis and treatment.
Materials and Methods: From September 2018 to December 2020, samples (catheter, pus, tissue, swab, and urine) were collected from outpatients of hospitals in South Korea for molecular biological venereal disease testing. DNA was extracted and analyzed using real-time polymerase chain reaction.
Results: Of the 59,381 samples analyzed, 8.78% (n=5,215) were positive for MG and MH. The MH positivity rate (5.51%, n=3,273) was higher than the MG positivity rate (3.27%, n=1,942). MG and MH positivity rates were the highest in patients aged <19 years. Men had higher MG positivity rate, whereas women had higher MH positivity rates. Furthermore, the MGpositivity rate was the highest in the swab samples of both men and women, whereas that of MH was the highest in the urine samples of men and swab samples of women.
Conclusion: We identified the differences between MG and MH positivity rates based on sex, specimen, and age. Our findings can provide information for strategies that protect public health and reduce STI incidence and transmission.
2. World Health Organization. Sexually transmitted infections (STIs). 2019. http://www.who.int/mediacentre/factsheets/fs110/en/ (Accessed 14 Jun 2019)
3. Centers for Disease Control and Prevention. Sexually transmitted disease (STDs). 2021. https://www.cdc.gov/std/default.htm (Accessed 25 Jan 2021)
4. Rezaei keykhaei K, Rajabpour Nikoo N, Vaez H, Rezaei keikhaei L, Shirazi M, Ghaemi M, et al. Investigating the prevalence of Mycoplasma genitalium and Mycoplasma hominis among women with vaginal infection in Zabol in 2017. J Obstet Gynecol Cancer Res 2019; 4: 141-145.
5. Choe HS, Lee DS, Lee SJ, Hong SH, Park DC, Lee MK, et al. Performance of Anyplex™ II multiplex real-time PCR for the diagnosis of seven sexually transmitted infections: comparison with currently available methods. Int J Infect Dis 2013; 17: e1134-e1140.
6. Park JO, Jeon JS, Kim JW, Kim JK. Epidemiological trends of sexually transmitted infections among women in Cheonan, South Korea, 2011–2017. Microbiol Biotechnol Lett 2018; 46: 85-90.
7. Yamazaki T, Matsumoto M, Matsuo J, Abe K, Minami K, Yamaguchi H. Frequency of Chlamydia trachomatis in Ureaplasma-positive healthy women attending their first prenatal visit in a community hospital in Sapporo, Japan. BMC Infect Dis 2012; 12: 82.
8. Moridi K, Ghazvini K, Hemmaty M, Hoseiniun H, Torkaman M, Fallah Mehrabadi MH. Prevalence determination of M. hominis and M. genitalium in the semen samples in the northeast of Iran using culture and multiplex polymerase chain reaction. Arch Razi Inst 2021; 76: 41-49.
9. Fookes MC, Hadfield J, Harris S, Parmar S, Unemo M, Jensen JS, et al. Mycoplasma genitalium: whole genome sequence analysis, recombination and population structure. BMC Genomics 2017; 18: 993.
10. Wiesenfeld HC, Manhart LE. Mycoplasma genitalium in women: current knowledge and research priorities for this recently emerged pathogen. J Infect Dis 2017; 216(suppl_2): S389-S395.
11. Horner PJ, Martin DH. Mycoplasma genitalium infection in men. J Infect Dis 2017; 216 (Suppl_2): S396-S405.
12. Ng KF, Kee Tan K, Chok MC, Zamil Mohd Muzzamil N, Choo P, Paramasivam U, et al. Mycoplasma hominis, Ureaplasma urealyticum and Chlamydia trachomatis respiratory colonization in Malaysian preterm infants. J Trop Pediatr 2017; 63: 447-453.
13. Yu N, Lee MK. Clinical implications of multiplex PCR detection of fastidious microorganisms in vaginitis patients. Korean J Clin Microbiol 2011; 14: 30-35.
14. Jeon JS, Kim JK. Epidemiological trends of sexually transmitted infections with Ureaplasma urealyticum among women in Cheonan, South Korea: 2006−2017. Microbiol Biotechnol Lett 2018; 46: 425-429.
15. Korea Disease Control and Prevention Agency. Infectious disease portal. 2021. http://www.kdca.go.kr/npt/biz/npp/iss/stisStatisticsMain.do (Accessed22 Jun 2021).
16. Baumann L, Cina M, Egli-Gany D, Goutaki M, Halbeisen FS, Lohrer GR, et al. Prevalence of Mycoplasma genitalium in different population groups: systematic review and meta-analysis. Sex Transm Infect 2018; 94: 255-262.
17. Adebamowo SN, Ma B, Zella D, Famooto A, Ravel J, Adebamowo C, et al. Mycoplasma hominis and Mycoplasma genitalium in the vaginal microbiota and persistent high-risk human papillomavirus infection. Front Public Health 2017; 5: 140.
18. Moridi K, Hemmaty M, Azimian A, Fallah MH, Khaneghahi Abyaneh H, Ghazvini K. Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019). BMC Public Health 2020; 20: 1020.
19. Liu WK, Chen DH, Tan WP, Qiu SY, Xu D, Zhang L, et al. Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey. Eur J Clin Microbiol Infect Dis 2019; 38: 2355-2364.
20. Liu T, Li Z, Zhang S, Song S, Julong W, Lin Y, et al. Viral etiology of acute respiratory tract infections in hospitalized children and adults in Shandong province, China. Virol J 2015; 12: 168.
| Files | ||
| Issue | Vol 13 No 5 (2021) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijm.v13i5.7423 | |
| Keywords | ||
| Sexually transmitted infection; Mycoplasma genitalium; Mycoplasma hominis; Infection | ||
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