Relationship between vitamin D levels and brucellosis: a case-control study from Sanandaj, Iran
-
Behzad Mohsenpour
,
Amjad Ahmadi
,
Anvar Mohammadi Baneh
,
Ebrahim Ghaderi
,
Shahla Afrasiabian
,
Samaneh Azizi
,
Katayoon Hajibagheri
Abstract
Background and Objectives: Brucellosis is a zoonotic disease that is caused by the Brucella species. This disease is common in Iran and its incidence is increasing .This study measures serum vitamin D levels in patients with brucellosis and healthy people.
Materials and Methods: This research was conducted as a case-control study at Tohid Hospital, Sanandaj, Iran. The calculated sample size included 90 patients in the case group and 90 patients in the control group. The measurement of vitamin D levels in the case and control groups were performed by ELISA.
Results: The mean serum vitamin D level was 19.91 ng/ml in the case group and 22.87 ng/ml in the control group. (Serum vitamin D level <10 ng/mL is accepted as deficiency, 10-30 ng/mL as insufficiency, 30-100 ng/mL as sufficiency, and >100 ng/mL as toxicity).
Conclusion: There was no significant difference between the two groups in terms of vitamin D deficiency (p-value=0.097).
2. Mohsenpour B, Afrasiabian S, Hajibagheri K, Ghaderi E. Is wright test an appropriate screening test for diagnosis of brucellosis? Am J Infect Dis 2011;7:28-31.
3. Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J (2015). Harrison's Principles of Internal Medicine, 19e: Mcgraw-Hill.
4. Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis 2010;14(6):e469-478.
5. Seleem MN, Boyle SM, Sriranganathan N. Brucellosis: a re-emerging zoonosis. Vet Microbiol 2010;140:392-398.
6. Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1, 25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 2004;80(6 Suppl):1717S-1720S.
7. Van Belle TL, Gysemans C, Mathieu C. Vitamin D in autoimmune, infectious and allergic diseases: a vital player? Best Pract Res Clin Endocrinol Metab 2011;25:617-632.
8. Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord 2017;18:153-165.
9. Rao Muvva J, Parasa VR, Lerm M, Svensson M, Brighenti S. Polarization of human monocyte-derived cells with vitamin D promotes control of Mycobacterium tuberculosis infection. Front Immunol 2020;10:3157.
10. Ganmaa D, Uyanga B, Zhou X, Gantsetseg G, Delgerekh B, Enkhmaa D, et al. Vitamin D supplements for prevention of tuberculosis infection and disease. N Engl J Med 2020;383:359-368.
11. Rahman AH, Branch AD. Vitamin D for your patients with chronic hepatitis C? J Hepatol 2013;58:184-189.
12. Salahuddin N, Ali F, Hasan Z, Rao N, Aqeel M, Mahmood F. Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis’. BMC Infect Dis 2013;13:22.
13. Murdoch DR, Slow S, Chambers ST, Jennings LC, Stewart AW, Priest PC, et al. Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial. JAMA 2012; 308:1333-1339.
14. Kurtaran B, Akyildiz O, Ulu AC, Inal SA, Komur S, Seydaoglu G, et al. The relationship between brucellosis and vitamin D. J Infect Dev Ctries 2016;10:176-182.
| Files | ||
| Issue | Vol 13 No 2 (2021) | |
| Section | Short Communication | |
| DOI | https://doi.org/10.18502/ijm.v13i2.5987 | |
| Keywords | ||
| Brucellosis; Vitamin D | ||
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