Human bocavirus infections among children less than two years old in Iran during fall and winter 2012-2013
Background and Objectives: Human bocavirus (HBoV) is a newly discovered parvovirus. It has been detected primarily in children with acute respiratory tract infections. This study was conducted to clarify the frequency and genotype circulation pattern of HBoV in Iran.
Materials and Methods: Conventional PCR was performed on throat swabs of patients less than two years of age with respiratory illnesses during fall and winter 2012-2013.
Results: HBoV virus DNA was detected in 15 of 140 samples (10.7 %). Sequencing and phylogenetic analysis on 5 samples showed that all were HBoV1. The positive samples were negative for influenza A and B viruses while co-infection with RSV was found in 2 (13.3%).
Conclusion: This study adds to the body of knowledge about the role of HBoV in acute respiratory illnesses in children in Iran.
Lau SK, Yip CC, Que TL, Lee RA, Au-Yeung RK, Zhou B, et al. Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong. J Infect Dis 2007; 196: 986-993.
Suzuki A, Lupisan S, Furuse Y, Fuji N, Saito M, Tama- ki R, et al. Respiratory viruses from hospitalized chil- dren with severe pneumonia in the Philippines. BMC Infect Dis 2012; 12: 267.
De Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coro- navirus Study Group. J Virol 2013; 87: 7790-7792.
Kapoor A, Slikas E, Simmonds P, Chieochansin T, Naeem A, Shaukat S, et al. A newly identified boca- virus species in human stool. J Infect Dis 2009; 199:196-200.
Kapoor A. Simmonds P, Slikas E, Li L, Bodhidatta L, Sethabutr O, et al. Human bocaviruses are highly di- verse, dispersed, recombination prone, and prevalent in enteric infections. J Infect Dis 2010; 201: 1633-1643.
Arthur JL, Higgins GD, Davidson GP, Givney RC, Rat- cliff RM. A novel bocavirus associated with acute gas- troenteritis in Australian children. PLoS Pathog 2009;5: e1000391.
Allander, T. Human bocavirus. J Clin Virol 2008; 41:29-33.
Allander T, Jartti T, Gupta S, Niesters HG, Lehtinen P, Osterback R, et al. Human bocavirus and acute wheez- ing in children. Clin Infect Dis 2007; 44: 904-910.
Peltola V,Söderlund-Venermo M, Jartti T. Human boca virus infections. Pediatr Infect Dis J 2013; 32:178-179.
Maggi F, Andreoli E, Pifferi M, Meschi S, Rocchi J, Bendinelli M. Human bocavirus in Italian patients with respiratory diseases. J Clin Virol 2007; 38: 321-325.
Zhao B, Yu X, Wang C,Teng Z, Wang C, Shen J, et al. High human bocavirus viral load is associated with disease severity in children under five years of age. PLoS One 2013; 8: e62318.
Deng Y, Gu X, Zhao X, Luo J, Luo Z, Wang L, et al.
High viral load of human bocavirus correlates with du- ration of wheezing in children with severe lower respi- ratory tract infection. PLoS One 2012; 7: e34353.
Jartti T, Hedman K, Jartti L, Ruuskanen O, Allander T, Söderlund-Venermo M. Human bocavirus-the first 5 years. Rev Med Virol 2012; 22: 46-64.
Nadji SA, Poos-Ashkan L, Khalilzadeh S, Baghaie N, Shiraghaei MJ, Hassanzad M, et al. Phylogenetic anal- ysis of human bocavirus isolated from children with acute respiratory illnesses and gastroenteritis in Iran. Scand J Infect Dis 2010; 42: 598-603.
Naghipour M, Cuevas LE, Bakhshinejad T, Dove W, Hart CA. Human bocavirus in Iranian children with acute respiratory infections. J Med Virol 2007; 79: 539-543.
Lindner J and Modrow S. Human bocavirus--a novel parvovirus to infect humans. Intervirology 2008; 51:116-122.
Christensen A, Nordbø SA, Krokstad S, Rognlien AG, Døllner H.Human bocavirus commonly involved in multiple viral airway infections. J Clin Virol 2008; 41:34-37.
|Issue||Vol 8 No 1 (2016)|
|Human bocavirus genotype children Iran|
|Rights and permissions|
|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|