Articles

Small Colony variants of Staphylococcus aureus isolated from a patient with infective endocarditis: a case report and review of the literature

Abstract

Staphylococcus aureus produces a particular morphological variant called small colony variant (SCV) which is responsible for persistent subclinical infections in predisposed individuals and is usually resistant to aminoglycosides and cell wall active antibiotics. Infections by SCV of S. aureus are an upcoming problem due to difficulty in laboratory diagnosis and resistance to antimicrobial chemotherapy. We here report a case of infective endocarditis caused by SCV of Staphylococcus aureus in a pediatric patient.

Seifert H, Wisplinghoff H, Schnabel P, von Eiff C.Small Colony variants of Staphylococcus aureus and Pacemaker related infection. Emerg Inf Dis 2003; 9: 1316-18.

Sendi P, Proctor Ra.Staphylococcus aureus as an intracellular pathogen: the role of small colony variants.Trends Microbiol 2009; 17: 54-58.

Samuelsen O, Haukland HH, Kahl BC, von Eiff C, Proctor RA, Ulvatne H, et al. Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide Lactoferrin B. J Antimicrob Chemother 2005;56: 1126-29.

Kahl BC, Belling G, Reichelt R, Herrmann M, Proctor RA, Peters G. Thymidine Dependent small colony variants of Staphylococcus aureus exhibit gross morphological and ultrastructural changes consistent with impaired cell separation. J Clin Microbiol 2003;41: 410-13.

Morellion P, Que YA, Glauser MP (2005).Staphylococcus aureus (including Staphylococcal toxic shock). In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 6 th ed. pp. 2323. Elsevier Churchill Livingstone. Philadelphia.

Al Hashimi H, Al Windy N, McGhie JC, Galema TW, ten Cate FJ, Simoons ML. Role of echocardiography in the diagnosis and management of infective endocarditis. Netherlands Heart J 2004; 12: 64-68

Files
IssueVol 4 No 2 (2012) QRcode
SectionArticles
Keywords
Auxotrophicity Menadione Small colony variant Staphylococcus aureus

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Bhattacharyya S, Roy S, Mukhopadhyay P, Rit K, Dey J, Ganguly U, Ray R. Small Colony variants of Staphylococcus aureus isolated from a patient with infective endocarditis: a case report and review of the literature. Iran J Microbiol. 1;4(2):98-99.