Seroprevalence of Hepatitis E Virus infection among volunteer blood donors in central province of Iran in 2012
-
Hassan Ehteram
,
Amitis Ramezani
,
Ali Eslamifar
,
Masoomeh Sofian
,
Mohammad Banifazl
,
Shahin Ghassemi
,
Arezoo Aghakhani
,
Parisa Mashayekhi
Abstract
Background and Objectives: Hepatitis E virus (HEV) is a major public health concern in developing countries. HEV transmission occurs primarily by the fecal-oral route. It has also been reported that blood donors are potentially able to cause transfusion-associated hepatitis E in endemic areas. This study aimed to determine the seroprevalence of HEV infection among volunteer blood donors in Central province of Iran in 2012.
Material and Methods: A total of 530 consecutive blood donor samples collected from Blood Transfusion Organization, Central Province of Iran. All samples were tested for the presence of IgG Hepatitis E antibody (anti-HEV) using enzyme- linked immunosorbent assay (ELISA).
Results: From 530 blood donors, 91.9% were male and 8.1% were female. Overall, anti-HEV was found in 76 of 530 samples (14.3%). There was no significant difference in HEV seropositivity between the subjects regarding gender and area of residence (urban vs. rural). Anti-HEV was distributed among all age groups. Although people aged 31-50 years had the highest prevalence, but there was no statistical difference between the age groups.
Conclusion: This study shows a relatively high prevalence of anti-HEV in the blood donors of Central province of Iran. More investigations are needed to assess the potential benefit of adding HEV screening of blood products to the current blood donor selection criteria.
Ataei B, Nokhodian Z, Javadi AA, Kassaian N, Shoaei P, Farajzadegan Z, et al. Hepatitis E virus in Isfahan Province: a population-based study. Int J Infect Dis 2009; 13: 67-71.
Keyvani H, Shamsi Shahrabadi M, Najafifard S, Hajibeigi B, Fallahian F, Alavian SM. Seroprevalence of anti-HEV and HEV RNA among volunteer blood donors and patients with Hepatitis B and C in Iran. Bangladesh Liver Journal 2009; 1: 34-37.
Ahn J, Kang SG, Lee DY, Shin SJ, Yoo HS.Identification of HEV isolates and determination of the seroprevalence of HEV in Korea. J Clin Microbiol 2005; 43: 3042-3048.
Cheng XF, Wen YF, Zhu M, Zhan SW, Zheng JX, Dong C, et al. Serological and molecular study of hepatitis E virus among illegal blood donors. World J Gastroenterol.2012; 18: 986-990.
Fukuda S, Sunaga J, Saito N, Fujimura K, Itoh Y, Sasaki M, et al. Prevalence of antibodies to hepatitis E virus among Japanese blood donors: identification of three blood donors infected with a genotype 3 hepatitis E virus. J Med Virol 2004; 73: 554-561.
Kaufmann A, Kenfak-Foguena A, André C, Canellini G, Bürgisser P, Moradpour D, et al. Hepatitis E virus seroprevalence among blood donors in southwest Switzerland. PLoS One 2011; 6: e21150.
Purcell RH, Emerson SU. Hepatitis E: an emerging awareness of an old disease. J Hepatol 2008; 48: 494-503.
Okamoto H. Genetic variability and evolution of hepatitis E virus. Virus Res 2007; 127: 216-228.
Aggarwal R. The Global Prevalence of Hepatitis E Virus Infection and Susceptibility: A Systematic Review. Geneva, Switzerland: WHO; 2010.
Acharya SK, Panda SK. Hepatitis E virus: epidemiology, diagnosis, pathology and prevention. Trop Gastroenterol 2006; 27: 63-68.
Yazaki Y, Mizuo H, Takahashi M, Nishizawa T, Sasaki N, Gotanda Y, et al. Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food. J Gen Virol 2003; 84: 2351-2357.
Tei S, KitajimaN, Takahashi K,Mishiro S. Zoonotic transmission of hepatitis E virus from deer to human beings. Lancet 2003; 362: 371-373.
Arankalle VA, Chobe LP. Hepatitis E virus: Can it be transmitted parenterally? J Viral Hep 1999; 6: 161-164.
Arankalle VA, Chobe LP. Retrospective analysis of blood transfusion recipients: Evidence for post- transfusion hepatitis E. Vox Sang 2000; 79 :72-74.
Taremi M, Gachkar L, MahmoudArabi S, Kheradpezhouh M, Khoshbaten M. Prevalence of antibodies to hepatitis E virus among male blood donors in Tabriz, Islamic Republic of Iran. East Mediterr Health J 2007; 13: 98-102.
Taremi M, Khoshbaten M, Gachkar L, Ehsani Ardakani M, Zali M. Hepatitis E virus infection in hemodialysis patients: a seroepidemiological survey in Iran. BMC Infect Dis 2005; 5: 36.
Taremi M, Mohammad Alizadeh AH, Ardalan A, Ansari S, Zali MR. Seroprevalence of hepatitis E in Nahavand, Islamic Republic of Iran: a population-based study. East Mediterr Health J 2008; 14: 157-1562.
Boxall E, Herborn A, Kochethu G, Pratt G, Adams D, Ijaz S, et al. Transfusion-transmitted hepatitis E in a ‘nonhyperendemic’ country. Transfus Med 2006; 16:79-83.
Tamura A, Shimizu YK, Tanaka T, Kuroda K, Arakawa Y, Takahashi K, et al. Persistent infection of hepatitis E virus transmitted by blood transfusion in a patient with T-cell lymphoma. Hepatol Res 2007; 37: 113-120.
Matsubayashi K, Kang JH, Sakata H, Takahashi K, Shindo M, Kato M, et al. A case of transfusion- transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus zoonotic food-borne route. Transfusion 2008; 48: 1368-1375.
Assarehzadegan MA, Shakerinejad G, Amini A, Rezaee SA. Seroprevalence of hepatitis E virus in blood donors in Khuzestan Province, southwest Iran. Int J Infect Dis 2008; 12: 387-390.
Aminafshar S, Alimagham M, Gachkar L, Yousefi F, Attarchi Z. Anti-hepatitis E virus seropositivity in a group of blood donors. Iran J Public Health 2004;
:53-56.
Meng XJ. Novel strains of hepatitis E virus identified from humans and other animal species: Is hepatitis E a zoonosis? J Hepatol 2000; 33: 842-845.
Emerson SU, Purcell RH. Hepatitis E virus. Rev Med Virol 2003; 13: 145-154.
Okamoto H, Takahashi M, Nishizawa T. Features of hepatitis E virus infection in Japan. Intern Med 2003;42: 1065-1071.
Alavian SM. Hepatitis E Virus Infection: A Neglected Problem in Our Region. Hepat Mon 2007; 7: 119-121.
Safar MJ, Khalilian A, Farhadi R, Babamohmoodi F.Seroepidemiology of HEV infection in 2-25 years of saravi in 2004. J Mazandaran Univ Med Sci 2005; 75:82-85.
Ghadir M, Jafari E, Rezvan H, Amini Kafiabad S, Vahezjavadi M, Pourshams A. Hepatitis A and E in the east of Golestan province. J Med Council IRI 2007; 25:34-38.
Mohebbi SR, Rostami Nejad M, Tahaei SM, Pourhoseingholi MA, Habibi M, Azimzadeh P, et al. Seroepidemiology of hepatitis A and E virus infections in Tehran, Iran: a population based study. Trans R Soc Trop Med Hyg 2012; 106: 528-531.
Rezazadeh M, Hahiloui M, Ghachkar L, Iadegari D, Kashani KM, Naghdi M. Study of antibody prevalence against Hepatitis E in blood donors in Hamedan. Infect Trop Dis 2005; 11: 13-18.
Gachkar L, Taremi M, Mahmoodarabi S, Kheradpajooh M, Dehkhoda R, Torabi SE. Frequency of antibodies to hepatitis E virus among male blood donors in Tabriz. Blood 2005; 2: 157-162.
Zanetti AR, Dawson GJ. Hepatitis type E in Italy: a seroepidemiological survey. Study Group of Hepatitis E. J Med Virol 1994; 42: 318-320.
Christensen PB, Engle RE, Hjort C, Homburg KM, Vach W, Georgsen J, et al. Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark. Clin Infect Dis 2008;47: 1026-1031.
Bortoliero AL, Bonametti AM, Morimoto HK, Matsuo T, Reiche EM. Seroprevalence for hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná, Brazil. Rev Inst Med Trop Sao Paulo 2006; 48: 87-92.
Guo QS, Yan Q, Xiong JH, Ge SX, Shih JW, Ng MH, et al. Prevalence of hepatitis E virus in Chinese blood donors. J Clin Microbiol 2010; 48: 317-8.
Irani Hakime N, Feghali Haibeh R. Hepatitis E virus: detection of antibodies in blood donors in Lebanon. J Med Liban 1998; 46: 60-62.37. Abdel Hady SI, El-Din MS, El-Din ME. A high hepatitis E virus (HEV) seroprevalence among unpaid blood donors and haemodialysis patients in Egypt. J Egypt Public Health Assoc 1998; 73: 165-179.
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| Issue | Vol 5 No 2 (2013) | |
| Section | Articles | |
| Keywords | ||
| Blood donor Hepatitis E virus (HEV) Seroprevalence | ||
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