Lessons from an 11-year retrospective cohort study of Escherichi coli causing UTI in Imam Hospital Ardabil, Iran
-
Pegah Shakib
,
Mohsen Arzanlou
,
Pouria Sobhi
,
Mehdi Mojebi
,
Mohammad Bahrami
,
Faraz Mahdizadeh
,
Leyla Asadi
,
Masoud Amanzadeh
,
Alireza Mohammadnia
,
Farzad Khademi
,
Rashid Ramazanzadeh
Abstract
Background and Objectives: The global problem of urinary tract infections (UTIs) caused by antibiotic-resistant bacteria is due to limited treatment options. This study aimed to examine the prevalence, etiology, and management implications of Escherichi coli causing UTI at Imam Hospital Ardabil, Iran.
Materials and Methods: 2340 samples of retrospective data on E. coli causing UTIs were collected at Imam Hospital in Ardabil, Iran, spanning from 2012 to 2022. The samples were cultured and isolated, and their antibiotic susceptibility was determined using standard laboratory methods and data were then organized and systematically categorized using Python.
Results: It was found that the lowest level of resistance was related to nitrofurantoin, followed by imipenem. In 2018, the number of E. coli patients resistant to trimethoprim was the highest. Cephalexin and ciprofloxacin trends indicate the reduction of the line during this retrospective period. There was a significant correlation between wards and some antibiotics like Cefepime, Cefotaxime, Ceftazidime, and Trimethoprim (P-Value <0.05).
Conclusion: Significant correlations were identified between specific hospital wards and resistance to antibiotics. These findings underscore the need for continuous surveillance and tailored antibiotic stewardship programs to combat the rising trend of antibiotic resistance.
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13. Sharma N, Gupta A, Walia G, Bakhshi R. Pattern of antimicrobial resistance of Escherichia coli isolates from urinary tract infection patients: A three year retrospective study. J Appl Pharm Sci 2016; 6: 062-065.
14. Neamati F, Firoozeh F, Saffari M, Zibaei M. Virulence genes and antimicrobial resistance pattern in uropathogenic Escherichia coli isolated from hospitalized patients in Kashan, Iran. Jundishapur J Microbiol 2015; 8(2): e17514.
15. Alanazi MQ, Alqahtani FY, Aleanizy FS. An evaluation of E. coli in urinary tract infection in emergency department at KAMC in Riyadh, Saudi Arabia: retrospective study. Ann Clin Microbiol Antimicrob 2018; 17: 3.
16. Kader AA, Kumar A. Prevalence and antimicrobial susceptibility of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a general hospital. Ann Saudi Med 2005; 25: 239-242.
17. Al-Tawfiq JA, Anani AA. Antimicrobial susceptibility pattern of bacterial pathogens causing urinary tract infections in a Saudi Arabian hospital. Chemotherapy 2009; 55: 127-131.
18. Sahm DF, Thornsberry C, Mayfield DC, Jones ME, Karlowsky JA. Multidrug-resistant urinary tract isolates of Escherichia coli: prevalence and patient demographics in the United States in 2000. Antimicrob Agents Chemother 2001; 45: 1402-1406.
19. Arredondo-García JL, Amábile-Cuevas CF. High resistance prevalence towards ampicillin, co-trimoxazole and ciprofloxacin, among uropathogenic Escherichia coli isolates in Mexico City. J Infect Dev Ctries 2008; 2: 350-353.
20. Bean DC, Krahe D, Wareham DW. Antimicrobial resistance in community and nosocomial Escherichia coli urinary tract isolates, London 2005–2006. Ann Clin Microbiol Antimicrob 2008; 7: 13.
21. Karlowsky JA, Kelly LJ, Thornsberry C, Jones ME, Sahm DF. Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States. Antimicrob Agents Chemother 2002; 46: 2540-2545.
22. Klingeberg A, Noll I, Willrich N, Feig M, Emrich D, Zill E, et al. Antibiotic-resistant E. coli in uncomplicated community-acquired urinary tract infection. Dtsch Arztebl Int 2018; 115: 494-500.
2. Sugianli AK, Ginting F, Parwati I, de Jong MD, van Leth F, Schultsz C. Antimicrobial resistance among uropathogens in the Asia-Pacific region: A systematic review. JAC Antimicrob Resist 2021; 3: dlab003.
3. Mhana SMY, Aljanaby AAJ. Bacteriological investigation of pathogenic bacteria causing urinary tract infections: A Cross-Sectional Study. IOP Conf Ser Earth Environ Sci 2023; 1215: 012067.
4. Niranjan V, Malini A. Antimicrobial resistance pattern in Escherichia coli causing urinary tract infection among inpatients. Indian J Med Res 2014; 139: 945-948.
5. Issakhanian L, Behzadi P. Antimicrobial agents and urinary tract infections. Curr Pharm Des 2019; 25: 1409-1423.
6. Dougnon V, Assogba P, Anago E, Déguénon E, Dapuliga C, Agbankpè J, et al. Enterobacteria responsible for urinary infections: a review about pathogenicity, virulence factors and epidemiology. J Appl Biol Biotechnol 2020; 8: 117-124.
7. Bunduki GK, Heinz E, Phiri VS, Noah P, Feasey N, Musaya J. Virulence factors and antimicrobial resistance of uropathogenic Escherichia coli (UPEC) isolated from urinary tract infections: a systematic review and meta-analysis. BMC Infect Dis 2021; 21: 753.
8. Yadav M, Pal R, Damrolien S, Khumanthem S. Microbial spectrum of urinary tract infections and its antibiogram in a tertiary care hospital. Int J Res Med Sci 2017; 5: 2718-2722.
9. Yogo N, Shihadeh K, Young H, Calcaterra SL, Knepper BC, Burman WJ, et al. Intervention to reduce broad-spectrum antibiotics and treatment durations prescribed at the time of hospital discharge: a novel stewardship approach. Infect Control Hosp Epidemiol 2017; 38: 534-541.
10. Mcquiston Haslund J, Rosborg Dinesen M, Sternhagen Nielsen AB, Llor C, Bjerrum L. Different recommendations for empiric first-choice antibiotic treatment of uncomplicated urinary tract infections in Europe. Scand J Prim Health Care 2013; 31: 235-240.
11. Bader MS, Loeb M, Brooks AA. An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgrad Med 2017; 129: 242-258.
12. Ahmed SS, Shariq A, Alsalloom AA, Babikir IH, Alhomoud BN. Uropathogens and their antimicrobial resistance patterns: Relationship with urinary tract infections. Int J Health Sci (Qassim) 2019; 13: 48-55.
13. Sharma N, Gupta A, Walia G, Bakhshi R. Pattern of antimicrobial resistance of Escherichia coli isolates from urinary tract infection patients: A three year retrospective study. J Appl Pharm Sci 2016; 6: 062-065.
14. Neamati F, Firoozeh F, Saffari M, Zibaei M. Virulence genes and antimicrobial resistance pattern in uropathogenic Escherichia coli isolated from hospitalized patients in Kashan, Iran. Jundishapur J Microbiol 2015; 8(2): e17514.
15. Alanazi MQ, Alqahtani FY, Aleanizy FS. An evaluation of E. coli in urinary tract infection in emergency department at KAMC in Riyadh, Saudi Arabia: retrospective study. Ann Clin Microbiol Antimicrob 2018; 17: 3.
16. Kader AA, Kumar A. Prevalence and antimicrobial susceptibility of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a general hospital. Ann Saudi Med 2005; 25: 239-242.
17. Al-Tawfiq JA, Anani AA. Antimicrobial susceptibility pattern of bacterial pathogens causing urinary tract infections in a Saudi Arabian hospital. Chemotherapy 2009; 55: 127-131.
18. Sahm DF, Thornsberry C, Mayfield DC, Jones ME, Karlowsky JA. Multidrug-resistant urinary tract isolates of Escherichia coli: prevalence and patient demographics in the United States in 2000. Antimicrob Agents Chemother 2001; 45: 1402-1406.
19. Arredondo-García JL, Amábile-Cuevas CF. High resistance prevalence towards ampicillin, co-trimoxazole and ciprofloxacin, among uropathogenic Escherichia coli isolates in Mexico City. J Infect Dev Ctries 2008; 2: 350-353.
20. Bean DC, Krahe D, Wareham DW. Antimicrobial resistance in community and nosocomial Escherichia coli urinary tract isolates, London 2005–2006. Ann Clin Microbiol Antimicrob 2008; 7: 13.
21. Karlowsky JA, Kelly LJ, Thornsberry C, Jones ME, Sahm DF. Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States. Antimicrob Agents Chemother 2002; 46: 2540-2545.
22. Klingeberg A, Noll I, Willrich N, Feig M, Emrich D, Zill E, et al. Antibiotic-resistant E. coli in uncomplicated community-acquired urinary tract infection. Dtsch Arztebl Int 2018; 115: 494-500.
| Files | ||
| Issue | Vol 16 No 6 (2024) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijm.v16i6.17246 | |
| Keywords | ||
| Urinary tract infection (UTI); Multidrug-resistance (MDR); Escherichia coli (E. coli); Iran; Retrospective studies; Cohort studies | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Shakib P, Arzanlou M, Sobhi P, Mojebi M, Bahrami M, Mahdizadeh F, Asadi L, Amanzadeh M, Mohammadnia A, Khademi F, Ramazanzadeh R. Lessons from an 11-year retrospective cohort study of Escherichi coli causing UTI in Imam Hospital Ardabil, Iran. Iran J Microbiol. 2024;16(6):737-744.
