The microbiology, epidemiology, risk factors, and clinical therapy of candidemia in burn patients hospitalized in Velayat Teaching Hospital, Rasht, northern Iran
,
Abstract
Background and Objectives: The study aimed to investigate the epidemiology and clinical therapy of candidemia in burn patients hospitalized in Velayat Hospital, Rasht, Iran.
Materials and Methods: The blood samples of suspected patients were cultured and PCR-sequencing was performed. Antifungal susceptibility testing was done by the CLSI M27-A4 document.
Results: Four blood samples were identified as positive. Candida parapsilosis complex (3 out of 4, 75%) was the predominant leading cause of candidemia. MIC values showed that all isolates were susceptible to itraconazole, amphotericin B, and 5-flucytosine.
Conclusion: It seems necessary to pay attention to Candida non-albicans species in antifungal therapy.
1. Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Primers 2020; 6: 11.
2. Luck ME, Herrnreiter CJ, Choudhry MA. Gut microbial changes and their contribution to post-burn pathology. Shock 2021; 56: 329-344.
3. D'Abbondanza JA, Shahrokhi S. Burn infection and burn sepsis. Surg Infect (Larchmt) 2021; 22: 58-64.
4. Ballard J, Edelman L, Saffle J, Sheridan R, Kagan R, Bracco D, et al. Positive fungal cultures in burn patients: a multicenter review. J Burn Care Res 2008; 29: 213-221.
5. Rafat Z, Sasani E, Salimi Y, Hajimohammadi S, Shenagari M, Roostaei D. The prevalence, etiological agents, clinical features, treatment, and diagnosis of HIV-associated oral candidiasis in pediatrics across the world: a systematic review and meta-analysis. Front Pediatr 2021; 9: 805527.
6. Raja NS. Epidemiology, risk factors, treatment and outcome of Candida bloodstream infections because of Candida albicans and Candida non‐albicans in two district general hospitals in the United Kingdom. Int J Clin Pract 2021; 75(1): e13655.
7. Halvaee S, Daie-Ghazvini R, Hashemi SJ, Khodavaisy S, Rahimi-Foroushani A, Bakhshi H, et al. A mycological and molecular epidemiologic study on onychomycosis and determination in vitro susceptibilities of isolated fungal strains to conventional and new antifungals. Front Cell Infect Microbiol 2021; 11: 693522.
8. Verma N, Roy A, Singh S, Pradhan P, Garg P, Singh M. Factors determining the mortality in cirrhosis patients with invasive candidiasis: A systematic review and meta-analysis. Med Mycol 2021; 60: myab069.
9. Clinical and Laboratory Standards Institute (CLSI) (2012). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Fourth International Supplement. CLSI Documents M27-S4, Clinical and Laboratory Standards Institute (CLSI), Wayne. https://www.scirp.org/reference/referencespapers?referenceid=1838540
10. Ranjbar-Mobarake M, Nowroozi J, Badiee P, Mostafavi SN, Mohammadi R. Cross-sectional study of candidemia from Isfahan, Iran: etiologic agents, predisposing factors, and antifungal susceptibility testing. J Res Med Sci 2021; 26: 107.
11. González GM, Elizondo M, Ayala J. Trends in species distribution and susceptibility of bloodstream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents: results of a 3-year (2004 to 2007) surveillance study. J Clin Microbiol 2008; 46: 2902-2905.
12. Cortés JA, Reyes P, Gómez C, Buitrago G, Leal AL; GREBO Group. Fungal bloodstream infections in tertiary care hospitals in Colombia. Rev Iberoam Micol 2011; 28: 74-78.
2. Luck ME, Herrnreiter CJ, Choudhry MA. Gut microbial changes and their contribution to post-burn pathology. Shock 2021; 56: 329-344.
3. D'Abbondanza JA, Shahrokhi S. Burn infection and burn sepsis. Surg Infect (Larchmt) 2021; 22: 58-64.
4. Ballard J, Edelman L, Saffle J, Sheridan R, Kagan R, Bracco D, et al. Positive fungal cultures in burn patients: a multicenter review. J Burn Care Res 2008; 29: 213-221.
5. Rafat Z, Sasani E, Salimi Y, Hajimohammadi S, Shenagari M, Roostaei D. The prevalence, etiological agents, clinical features, treatment, and diagnosis of HIV-associated oral candidiasis in pediatrics across the world: a systematic review and meta-analysis. Front Pediatr 2021; 9: 805527.
6. Raja NS. Epidemiology, risk factors, treatment and outcome of Candida bloodstream infections because of Candida albicans and Candida non‐albicans in two district general hospitals in the United Kingdom. Int J Clin Pract 2021; 75(1): e13655.
7. Halvaee S, Daie-Ghazvini R, Hashemi SJ, Khodavaisy S, Rahimi-Foroushani A, Bakhshi H, et al. A mycological and molecular epidemiologic study on onychomycosis and determination in vitro susceptibilities of isolated fungal strains to conventional and new antifungals. Front Cell Infect Microbiol 2021; 11: 693522.
8. Verma N, Roy A, Singh S, Pradhan P, Garg P, Singh M. Factors determining the mortality in cirrhosis patients with invasive candidiasis: A systematic review and meta-analysis. Med Mycol 2021; 60: myab069.
9. Clinical and Laboratory Standards Institute (CLSI) (2012). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Fourth International Supplement. CLSI Documents M27-S4, Clinical and Laboratory Standards Institute (CLSI), Wayne. https://www.scirp.org/reference/referencespapers?referenceid=1838540
10. Ranjbar-Mobarake M, Nowroozi J, Badiee P, Mostafavi SN, Mohammadi R. Cross-sectional study of candidemia from Isfahan, Iran: etiologic agents, predisposing factors, and antifungal susceptibility testing. J Res Med Sci 2021; 26: 107.
11. González GM, Elizondo M, Ayala J. Trends in species distribution and susceptibility of bloodstream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents: results of a 3-year (2004 to 2007) surveillance study. J Clin Microbiol 2008; 46: 2902-2905.
12. Cortés JA, Reyes P, Gómez C, Buitrago G, Leal AL; GREBO Group. Fungal bloodstream infections in tertiary care hospitals in Colombia. Rev Iberoam Micol 2011; 28: 74-78.
| Files | ||
| Issue | Vol 16 No 6 (2024) | |
| Section | Short Communication | |
| DOI | https://doi.org/10.18502/ijm.v16i6.17262 | |
| Keywords | ||
| Candidemia; Burns; Epidemiology; Microbiology; Microbial sensitivity tests | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Rafat Z, Roostaei D, Mobayen M, Salehiniya H, Pournasrolah P. The microbiology, epidemiology, risk factors, and clinical therapy of candidemia in burn patients hospitalized in Velayat Teaching Hospital, Rasht, northern Iran. Iran J Microbiol. 2024;16(6):835-838.
