Onychomycosis in north-East of Iran
Abstract
Background and Objectives: Onychomycosis is a common fungal infection which has been conducted in many parts of the world. The aim of this study was to evaluate the epidemiology and to identify the aetiological factors of onychomycosis in Mazandaran province, Iran.
Materials and Methods: During the period of 10 years (2003–2012) 1100 patients suspected with onychomycosis, referred to the Mycology Laboratory of the Referral Laboratory and Boali Sina Hospital of Mazanadaran University of Medical Sciences, Sari, Iran, were assessed for the presence of onychomycosis with mycological examination based on conventional techniques.
Results: Among 1100 subjects (398 males and 702 females, aged 1-88 years) onychomycosis was diagnosed in 625(56.8%) cases. Among cases of onychomycosis, laboratorial confirmation was reached through direct examination with positive cultures in 464 samples (74.3%), while only by positive direct exam in 114 cases (18.2 %) or just positive culture in 47 cases (7.5%). The results of fungal culture revealed Candida spp. isolated in (61.9%) of the cases as the most common agents of onychomycosis while among dermatophytes, Trichophyton mentagrophytes was found in 17.7% followed by T. rubrum (1.7%), Epidermophyton floccosum (0.7%), T. violaceum (0.2%), T. verrucosum (0.2%), T. tonsurans (0.2%) and Microsporum gypseum (0.2%). Among the non-dermatophyte moulds, Aspergillus spp. was the most prevalent species (14.2%).
Conclusion: The results demonstrated that onychomycosis was diagnosed in 625(56.8%) cases and the most common isolates were Candida spp., followed by dermatophytes and moulds. This epidemiological data collected may be useful in the development of preventive and educational strategies.
Faergemann J, Baran R. Epidemiology, clinical presentation and diagnosis of onychomycosis. Br J Dermatol 2003; 149: 1-4.
Nandedkar-Thomas MA, Escher RK. An update on disorders of the nails. J Am Acad Dermatol 2005; 52:877-877.
Perea S, Ramos MJ, Garau M, Gonzalez A, Noriega AR, del Palacio A. Prevalence and risk factors of tinea unguium and tinea pedis in the general population in Spain. J Clin Microbiol 2000; 38: 3226-3230.
Haneke E, Roseeuw D. The scope of onychomycosis:epidemiology and clinical features. Int J Dermatol 1999;38(Suppl. 2): 7-12.
Sigurgeisson B, Steingrimsson O. Risk factors associated with onychomycosis. J Eur Acad Dermatol Venereol 2004; 18: 48-51.
Cheng S, Chong L. A prospective epidemiological study on tinea pedis and onychomyocosis in Hong Kong. Chinese Medical Journal 2002; 115: 860-865.
Seebacher C, Bouchara JP, Mignon B. Updates on the epidemiology of dermatophyte infections. Mycopathologia 2008; 166: 335-352.
Gerami Shoar M, Zomorodian K, Emami M, Tarazoei B, Saadat F. Study and identification of the etiological agents of onychomycosis in Tehran, capital of Iran. Iranian J Publ Health 2002; 31: 100-104.
Shokohi T, Hajheidari Z, Haghani I, Khalilian A, Aghili SR, Miahi S. The study of 101 cases of onychomycosis and associate factors in patients referred to Boali Sina Hospital and Toba dermatology outpatient clinics in Sari. J Mazandaran Uni Med Sci 2009; 19: 33-43.
Chadeganipour M, Nilipour S, Ahmadi Gh. Study of onychomycosis in Isfahan, Iran. Mycoses 2008; 53:153-157.
Aghamirinia M R, Ghiasian S A. onychomycosis in Iran; epidemiological and causative agent and clinical features. Jpn J Med Mycol 2010; 51: 23-29.
Falahati M, Akhlaghi L, Lari AR, Alaghehbandan R.Epidemiology of dermatophytoses in an area south of Tehran, Iran. Mycopathologia 2003; 156: 279-287.
Svejgaard EL, Nilsson J. Onychomycosis in Denmark: prevalence of fungal nail infection in general practice. Mycoses 2004; 47: 131-135.
Pereiro M Jr, Toribio J. Epidemiology de onychomycose.Journal de Mycologie Medicale 2002; 12: 175-182.
Sais G, Jucgla A, Peyry J. Prevalence of dermatophytes onychomycosis in Spain: a cross sectional study. Br J Dermatol 1995; 132: 758-761.
Cheng S, Chong L. A prospective epidemiological study on tinea pedis and onychomyocosis in Hong Kong. Chinese Med J 2002; 115: 860-865.
Gunduz T, Metin DY, Sacar T, Hilmioglu S, Baydur H, Inci R, et al. Onychomycosis in primary school children: Association with socioeconomic conditions. Mycoses 2006; 49: 431-433.
Metintas S, Kiraz N, Arslantas D, Akgun Y, Kalyoncu C, Kiremitci A, et al. Frequency and risk factors of dermatophytosis in students living in rural areas in Eskiehir, Turkey. Mycopathologia 2004; 157: 379-382.
Raboobee N, Aboobaker J, Peer AK. Tinea pedis et unguium in the Muslim community of Durban, South Africa. International Journal of Dermatology 1998; 37:759-765.
Alvarez MI, Gonzalez LA, Castro LA: Onychomycosis in Cali, Colombia. Mycopathologia 2004; 158: 181-186.
Mercantini R, Marsella R, Moretto D. Onychomycosis in Rome, Italy. Mycopathologia 1996; 136: 25-32.
Ravinder Kaur, Bineeta Kashyap, Preena Bhalla.A five-year survey of onychomycosis in new delhi, india: epidemiological and laboratory aspects. Indian J Dermatol 2007; 52: 39-42.
Aman S, Haroon TS, Hussain I, Bokhari MA, Khurshid K. Tinea unguium in Lahore, Pakistan. Med Mycol 2001; 39: 177-180.
Banerjee U, Sethi M, Pasricha JS. Study of onycho- mycosis in India. Mycoses 1990; 33: 411-415.
Gupta AK, Jain HC, Lynde CW, Watteel GN, Summerbell RC. Prevalence and epidemiology of unsuspected onychomycosis in patients visiting derma- tologists’ offices in Ontario, Canada a ulticenter survey of 2100 patients. Int J Dermatol 1997; 36: 783-787.
Jorge O. Lopes, Sydney H. Alves, Cristine RD. Mari, Loiva TO, et al. A ten-year survey of onychomycosis in the central region of the rio grande do sul, Brazil. Rev. Inst. Med. trop. S. Paulo 1999; 41: 147-149.
Khosravi AR, Aghamirian MR, Mahmoudi M: Der- matophytoses in Iran. Mycoses 1994; 37: 43-8.
Hay R. Literature review: Onychomycosis. J Eur Acad Dermatol Venereol 2005; 19 (Suppl. 1): 1-7.
Nsanze H, Lestringant GG, Mustafa N, Usmani MA. Aetiology of onychomycosis in Al Ain, United Arab Emirates. Mycoses 1995; 38: 421-424.
Pontes ZB, Lima EdeO, Oliveira NM, Dos Santos JP, Ramos AL, Carvalho MF. Onychomycosis in Joao Pessoa city, Brazil. Rev Argent Microbiol 2002; 34:95-99.
Romano C, Gianni C, Difonzo EM. Retrospective study of onychomycosis in Italy: 1985-2000. Mycoses 2005;48: 42-44.
Aman S, Haroon TS, Hussain I, Bokhari MA, Khurshid K. Tinea unguium in Lahore, Pakistan. Med Mycol 2001; 39: 177-180.
Khosravi AR, Mansouri P. Onychomycosis in Tehran, Iran: prevailing fungi and treatment with itraconazole. Mycopathologia 2000; 150: 9-13.
Ng KP, Saw TL, Madasamy M, Soo Hoo TS.Onychomycosis in Malaysia. Mycopathologia 1999;147: 29-32.
Veer P, Patwardhan NS, Damle AS. Study of onychomycosis: prevailing fungi and pattern of infection. Indian J Med Microbiol 2007; 25: 53-56.
El sayed F, Ammoury A, Haybe RF, Dhaybi R. Onychomycosis in Lebanon: a mycological survey of 772 patients. Mycoses 2006; 49: 216-219.
Tsoumani M, Jelastopulu E, Bartzavali C, Vamvako- poulou S, Dimitracopoulos G, Anastassiou ED, et al. Changes of dermatophytoses in southwestern Greece:An 18-year survey. Mycopathologia 2011; 172: 63-67.
Leibovici V, Evron R, Dunchin M, Westerman M, Ingber A. A population-based study of toenail onychomycosis in Israeli children. Pediatr Dermatol 2009; 26: 95-97.
| Files | ||
| Issue | Vol 6 No 2 (2014) | |
| Section | Articles | |
| Keywords | ||
| Candida Dermatophytes Iran Nondermatophyte Onychomycosis | ||
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