Global prevalence of infections in newborns with respiratory complications: systematic review and meta-analysis
Abstract
Background and Objectives: Newborns as a vulnerable population are exposed to congenital and acquired infections during and after birth. There are several reports of the isolation and reporting of infectious agents (IAs) in early life of newborns with respiratory manifestations, and the present comprehensive study provides a snapshot of the current global situation of the prevalence of IAs in newborns with respiratory symptoms.
Materials and Methods: A systematic search was conducted in main databases, including PubMed, Scopus, Web of science, and Google scholar. The pooled prevalence of infectious agents (IAs) in newborns was estimated using comprehensive meta-analysis software based on random effects model.
Results: Out of 44 inclusive studies (50 datasets) for IAs in newborns, the pooled prevalence was estimated to be 12.2% (95% CI: 6.40-22.0%) and the highest and lowest prevalence of IAs was related to the Brazil (78.2%, 95% CI: 31.0-96.6%), and UK (0.01%, 95% CI 0.01-0.01%) respectively.
Conclusion: The high prevalence of IAs in newborns emphasizes considers the necessary measures to prevent respiratory infections.
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3. Luoto R, Jartti T, Ruuskanen O, Waris M, Lehtonen L, Heikkinen T. Review of the clinical significance of respiratory virus infections in newborn infants. Acta Paediatr 2016; 105: 1132-1139.
4. Karatekin G, Kaya A, Salihoğlu Ö, Balci H, Nuhoğlu A. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr 2009; 63: 473-477.
5. Vieira RA, Diniz EM, Vaz FA. Clinical and laboratory study of newborns with lower respiratory tract infection due to respiratory viruses. J Matern Fetal Neonatal Med 2003; 13: 341-350.
6. Moreno SC, To J, Chun H, Ngai IM. Vertical transmission of COVID-19 to the neonate. Infect Dis Obstet Gynecol 2020; 2020: 8460672.
7. Vittucci AC, Piccioni L, Coltella L, Ciarlitto C, Antilici L, Bozzola E, et al. The disappearance of respiratory viruses in children during the COVID-19 pandemic. Int J Environ Res Public Health 2021; 18: 9550.
8. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 2015; 4: 1.
9. Munn Z, Aromataris E, Tufanaru C, Stern C, Porritt K, Farrow J, et al. The development of software to support multiple systematic review types: the Joanna Briggs Institute System for the Unified Management, Assessment and Review of Information (JBI SUMARI). Int J Evid Based Healthc 2019; 17: 36-43.
10. Twisselmann B. Incidence of group B streptococcal infection in newborns may be higher than previously assumed. Euro Surveill 2000; 4: 1504.
11. Vieira SE, Stewien KE, Queiroz DA, Durigon EL, Török TJ, Anderson LJ, et al. Clinical patterns and seasonal trends in respiratory syncytial virus hospitalizations in São Paulo, Brazil. Rev Inst Med Trop Sao Paulo 2001; 43: 125-131.
12. Gagneur A, Sizun J, Vallet S, Legr MC, Picard B, Talbot PJ. Coronavirus-related nosocomial viral respiratory infections in a neonatal and paediatric intensive care unit: a prospective study. J Hosp Infect 2002; 51: 59-64.
13. Checon RE, Siqueira MM, Lugon AK, Portes S, Dietze R. Seasonal pattern of respiratory syncytial virus in a region with a tropical climate in Southerastern Brazil. Am J Trop Med Hyg 2002; 67: 490-491.
14. Benstein BD, Crouse DT, Shanklin DR, Ourth DD. Ureaplasma in lung: 2. Association with bronchopulmonary dysplasia in premature newborns. Exp Mol Pathol 2003; 75: 171-177.
15. Hoffman JA, Mason EO, Schutze GE, Tan TQ, Barson WJ, Givner LB, et al. Streptococcus pneumoniae infections in the neonate. Pediatrics 2003; 112: 1095-1102.
16. Fodha I, Landolsi N, Vabret A, Sboui H, Trabelsi A, Freymuth F. Epidemiology and clinical presentation of respiratory syncytial virus infection in a Tunisian neonatal unit from 2000 to 2002. Ann Trop Paediatr 2004; 24: 219-225.
17. Gonik B, Puder KS, Gonik N, Kruger M. Seroprevalence of Bordetella pertussis antibodies in mothers and their newborn infants. Infect Dis Obstet Gynecol 2005; 13: 59-61.
18. Abdulnabi GJ, Al-Chalabi AK. Isolation of ureaplasma urealyticum in newborn infants with respiratory distress. Med J Basrah Univ 2006; 24: 19-22.
19. Aydin B, Zenciroglu A, Dilli D, Okumus N, İpek MS, Aydın M, et al. Clinical course of community-acquired respiratory syncytial virus pneumonia in newborns hospitalized in neonatal intensive care unit. Tuberk Toraks 2013; 61: 235-244.
20. Smit PM, Pronk SM, Kaandorp JC, Weijer O, Lauw FN, Smits PH, et al. RT-PCR detection of respiratory pathogens in newborn children admitted to a neonatal medium care unit. Pediatr Res 2013; 73: 355-361.
21. Sobouti B, Fallah S, Mobayen M, Noorbakhsh S, Ghavami Y. Colonization of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women and their transmission to offspring. Iran J Microbiol 2014; 6: 219-224.
22. Mutlu M, Söğüt A, Kader Ş, Aslan Y. Respiratory syncytial virus outbreak prevention by screening neonates with respiratory infection, isolation and applying standard infection control procedures. J Neonatol Clin Pediatr 2015; 2: 006.
23. Lu L, Yan Y, Yang B, Xiao Z, Feng X, Wang Y, et al. Epidemiological and clinical profiles of respiratory syncytial virus infection in hospitalized neonates in Suzhou, China. BMC Infect Dis 2015; 15: 431.
24. Raouf RMKA-E, Imam SS, Fathy MM, El-Deen NNS, Husseiny AM. Molecular detection of Ureaplasma urealyticum and Ureaplasma parvum colonization in preterm infants with respiratory distress syndrome. Egypt J Med Microbiol 2016; 25: 17-24.
25. Rojas P, Friaza V, García E, de la Horra C, Vargas SL, Calderón EJ, et al. Early acquisition of Pneumocystis jirovecii colonization and potential association with respiratory distress syndrome in preterm newborn infants. Clin Infect Dis 2017; 65: 976-981.
26. Vera C, Aguilar YA, Vélez LA, Rueda ZV. High transient colonization by Pneumocystis jirovecii between mothers and newborn. Eur J Pediatr 2017; 176: 1619-1627.
27. Lee J-H, Cho S-Y, Kim M-J. Associated factors with respiratory virus detection in newborn with suspected infection. Perinatology 2017; 28: 134-139.
28. Maksić H, Heljić S, Skokić F, Šumanović-Glamuzina D, Milošević V, Zlatanović A, et al. Predictors and incidence of hospitalization due to respiratory syncytial virus (RSV)-associated lower respiratory tract infection (LRTI) in non-prophylaxed moderate-to-late preterm infants in Bosnia and Herzegovina. Bosn J Basic Med Sci 2018; 18: 279-288.
29. Kumar S, Kashyap P, Kumar NB, Kashyap B, Garg IB, Saigal SR. 2612. Molecular evidence of Ureaplasma urealyticum and Ureaplasma parvum colonization in preterm infants with respiratory distress. Open Forum Infect Dis 2019; 6(Suppl 2): S908.
30. Liu P, Zheng J, Yang P, Wang X, Wei C, Zhang S, et al. The immunologic status of newborns born to SARS-CoV-2–infected mothers in Wuhan, China. J Allergy Clin Immunol 2020; 146: 101-109. e1.
31. Nie R, Wang S-S, Yang Q, Fan C-F, Liu Y-L, He W-C, et al. Clinical features and the maternal and neonatal outcomes of pregnant women with coronavirus disease 2019. MedRxiv 2020; 10.1101/2020.03.22.20041061.
32. Manti S, Esper F, Alejandro‐Rodriguez M, Leonardi S, Betta P, Cuppari C, et al. Respiratory syncytial virus seropositivity at birth is associated with adverse neonatal respiratory outcomes. Pediatr Pulmonol 2020; 55: 3074-3079.
33. Xu S, Shao F, Bao B, Ma X, Xu Z, You J, et al. Clinical manifestation and neonatal outcomes of pregnant patients with coronavirus disease 2019 pneumonia in Wuhan, China. Open Forum Infect Dis 2020; 7: ofaa283.
34. Farghaly MA, Kupferman F, Castillo F, Kim RM. Characteristics of newborns born to SARS-CoV-2-positive mothers: a retrospective cohort study. Am J Perinatol 2020; 37: 1310-1316.
35. He Z, Fang Y, Zuo Q, Huang X, Lei Y, Ren X, et al. Vertical transmission and kidney damage in newborns whose mothers had coronavirus disease 2019 during pregnancy. Int J Antimicrob Agents 2021; 57: 106260.
36. Lubis BM. Clinical characteristics and outcomes of COVID-19 in newborn and infants. Int J Sci Res Manag 2021; 9: 329-334.
37. Cardona-Pérez JA, Villegas-Mota I, Helguera-Repetto AC, Acevedo-Gallegos S, Rodríguez-Bosch M, Aguinaga-Ríos M, et al. Prevalence, clinical features, and outcomes of SARS-CoV-2 infection in pregnant women with or without mild/moderate symptoms: Results from universal screening in a tertiary care center in Mexico City, Mexico. PLoS One 2021; 16(4): e0249584.
38. Egerup P, Olsen LF, Christiansen AH, Westergaard D, Severinsen ER, Hviid KVR, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies at delivery in women, partners, and newborns. Obstet Gynecol 2021; 137: 49-55.
39. Shlomai NO, Kasirer Y, Strauss T, Smolkin T, Marom R, Shinwell ES, et al. Neonatal SARS-CoV-2 infections in breastfeeding mothers. Pediatrics 2021; 147(5): e2020010918.
40. Sánchez-Luna M, Fernández Colomer B, de Alba Romero C, Alarcón Allen A, Baña Souto A, Camba Longueira F, et al. Neonates born to mothers with COVID-19: data from the Spanish society of neonatology registry. Pediatrics 2021; 147(2): e2020015065.
41. Solís-García G, Gutiérrez-Vélez A, Pescador Chamorro I, Zamora-Flores E, Vigil-Vázquez S, Rodríguez-Corrales E, et al. Epidemiology, management and risk of SARS-CoV-2 transmission in a cohort of newborns born to mothers diagnosed with COVID-19 infection. An Pediatr (Engl Ed) 2021; 94: 173-178.
42. Vazquez-Alejo E, Tarancon-Diez L, Carrasco I, Vigil-Vázquez S, Muñoz-Chapuli M, Rincón-López E, et al. SARS-CoV2 Infection during pregnancy causes persistent immune abnormalities in women without affecting the newborns. Front Immunol 2022; 13: 947549.
43. Szydłowicz M, Królak-Olejnik B, Vargas SL, Zajączkowska Ż, Paluszyńska D, Szczygieł A, et al. Pneumocystis jirovecii colonization in preterm newborns with respiratory distress syndrome. J Infect Dis 2022; 225: 1807-1810.
44. Morioka I, Toishi S, Kusaka T, Wada K, Mizuno K; Committee of Neonatal Medicine in Japan Pediatric Society. Medical care of newborns born to mothers with confirmed or suspected severe acute respiratory syndrome coronavirus 2 infections in Japan. Pediatr Int 2022; 64(1): e14855.
45. Pan J, Zhan C, Yuan T, Sun Y, Wang W, Chen L. Impact of the COVID-19 pandemic on infectious disease hospitalizations of neonates at a tertiary academic hospital: A cross-sectional study. BMC Infect Dis 2022; 22: 206.
46. Wallace B, Chang D, Woodworth K, DeSisto CL, Simeone R, Ko JY, et al. Illness severity indicators in newborns by COVID-19 status in the United States, March–December 2020. J Perinatol 2022; 42: 446-453.
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| Files | ||
| Issue | Vol 16 No 1 (2024) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijm.v16i1.14867 | |
| Keywords | ||
| Newborn; Communicable diseases; Infections; Respiratory tract diseases; Meta-analysis | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Zhao X, Zhang N. Global prevalence of infections in newborns with respiratory complications: systematic review and meta-analysis. Iran J Microbiol. 2024;16(1):19-28.
