Assessing the prevalence of bacterial vaginosis among infertile women of Qom city
Abstract
Background and Objectives: Bacterial vaginosis (BV) is a common disorder which happens when the balance of bacterial flora in vagina is disrupted by a shift in concentration of lactobacillus and pathogenic bacteria. It has significant sequelae including increased rates of late miscarriage when diagnosed in early pregnancy, premature rupture of the membranes, endometritis, preterm labour and delivery and tubal factor infertility. So it seems to be necessary to evaluate the prevalence of BV among women with primary infertility.
Material and Methods: All specimens were collected during vagina examination by use of a speculum and swabbing. A sampling swab was introduced into vaginal canal and rotated for at least 8 seconds before withdrawal. The vaginal swabs were examined in standard microbiological analysis including of microscopy, culture and sensitivity examination.
Results and Conclusion: Totally identified Gram positive bacteria were significantly higher in number than the Gram negative bacteria. We found that the prevalence of bacterial vaginosis as 70.34% among infertile women of Qom city. Staphylococcus aureus was the most prevalent vaginal pathogen (57.33%) followed by E. coli (25.33%). S. aureus showed maximum sensitivity to penicillin and gentamicin. It means that fortunately in Qom, this bacterium has not acquired resistance against penicillin yet. So, all physicians must have a high index of suspicion and use readily available screening methods to recognize and treat the patients with infectious vaginitis adequately.
Hay PE, Lamont RF, Taylor-Robinson D, Morgan DJ, Ison C, Pearson J. Abnormal bacterial colonization of the genital tract and subsequent preterm delivery and late miscarriage. BMJ 1994; 308: 295–298.
Flery FJ. Adult vaginitis. Clin Obstet Gynecol 1987;24:407–438.
Spiegel CA, Amsel R, Eschenbach D, Schoenknecht F, Holmes KK. Anaerobic bacteria in nonspecific vaginitis. N Engl J Med 1980; 303:601–607.
Hillier SL. Diagnostic microbiology of bacterial vaginosis. Am J Obstet Gynecol 1993;169: 455–459.
Yudin MH, Money DM; Infectious Diseases Committee.Screening and management of bacterial vaginosis in pregnancy. J Obstet Gynaecol Can 2008; 30: 702- 716.
Goldenberg R, Klebanoff M, Nugent R, Krohn M, Hillier S, Andrews W; for the Vaginal Infections and Prematurity Study Group. Bacterial colonization of the vagina during pregnancy in four ethnic groups. Am J Obstet Gynecol 1996; 174:1618–1621.
Jonsson M, Karlsson R, Rylander E, Gustavsson A, Wadell G. The associations between risk behavior and reported history of sexually transmitted diseases, among young women: a population based study. Int J STD AIDS 1997;8: 501–505.
Bump R, Buesching III WB. Bacterial vaginosis in virginal and sexually active adolescent females: evidence against exclusive sexual transmission. Am J Obstet Gynecol 1988; 158: 935–939.
Hawes SE, Hillier SL, Benedetti J, Stevens CE, Koutsky LA, Wolner-Hanssen P, et al. Hydrogen peroxide- producing lactobacilli and acquisition of vaginal infections. J Infect Dis 1996; 174: 1058–1063.
Zabrek EM. Can I get pregnant? The basic infertility workup. Clin Obstet Gynecol 1996 ; 39: 223-230.
Forti G, Krausz C. Clinical review 100: Evaluation and treatment of the infertile couple. J Clin Endocrinol Metab 1998; 83: 4177-4188.
Leanza V, Coco L, Grasso F, Leanza G, Zarbo G, Palumbo M. Unexplained infertility and ovulatory induction with menopausal gonadotropins. Minerva Ginecol 2014; 66: 303-307.
Rasheed M. Salah, Abdelmonem M. Allam, Amin M.Magdy, Abeer Sh. Mohamed. Eur J Obstet Gynecol Reprod Biol 2013; 167: 59–63.
Michael F. Rein and Bryan A. Liang. Diagnosis and treatment of infectious vaginitis. Hospital Physician 1999; 46 – 58.
Jean-Pierre Menard. Antibacterial treatment of bacterial vaginosis: current and emerging therapies. Int J Womens Heaith 2011; 3: 395-305.
Bump RC, Zuspan FP, Buesching WJ 3rd, Ayers LW, Stephens TJ. The prevalence, six-month persistence, and predictive values of laboratory indicators of bacterial vaginosis (nonspecific vaginitis) in asymptomatic women. Am J Obstet Gynecol 1984; 150: 917–924.
Hill LH, Ruperalia H, Embil JA. Nonspecific vaginitis and other genital infections in three clinic populations. Sex Transm Dis 1983; 10:114– 118.
Eschenbach DA, Hillier S, Critchlow C, Stevens C, DeRouen T, Holmes KK. Diagnosis and clinical manifestations of bacterial vaginosis. Am J Obstet Gynecol 1988; 158: 819–828.
Embree J, Caliando JJ, McCormack WM. Nonspecific vaginitis among women attending a sexually transmitted diseases clinic. Sex Transm Dis 1984; 11: 81–84.
Meis PJ, Goldenberg RL, Mercer B, Moawad A, Das A, McNellis D, et al. The preterm prediction study: significance of vaginal infections. Am J Obstet Gynecol 1995; 173: 1231–1235.
Wenman WM, Tataryn IV, Joffres MR, Pearson R, Grace MGA, Albritton WL, et al. Demographic, clinical and microbiological characteristics of maternity patients: a Canadian clinical cohort study. Can J Infect Dis 2002;13: 311–318.
Liversedge NH, Turner A, Horner PJ, Keay SD, Jenkins JM, Hull MG. The influence of bacterial vaginosis on in-vitro fertilization and embryo implantation during assisted reproduction treatment. Hum Reprod 1999; 14:2411-2415.
Mumtaz S, Ahmad M, Aftab I, Akhtar N, ul Hassan M, Hamid A. Aerobic vaginal pathogens and their sensitivity pattern. J Ayub Med Coll Abbottabad 2008;20:113- 117.
Khan I, Khan UA. A hospital based study of frequency of aerobic phatogens in vaginal infections. J Rawal Med Coll 2004; 29:22- 25.
Reid, G., Bruce, A.W. Urogenital infections in women:can probiotics help? Postgrad Med J 2003; 79, 428– 432.
Aslim, B., Kilic, E. Some probiotic properties of vaginal lactobacilli isolated from healthy women. Jpn J Infect Dis 2006; 59: 249–253.
Charlier C, Cretenet M, Even S, Le Loir Y. Interactions between Staphylococcus aureus and lactic acid bacteria: an old story with new perspectives. Int J Food Microbiol 2009; 131:30-39.
Mibbard LT, Snyder WJ, Subgluteal and retropsoas infections in obstetrical practice. J Obstet Gynecol 1972; 39: 137- 139.
Kent HL.Epidemiology of vaginitis. Am J Obster Gynecol 1991; 165: 1168-1176.
Hafiz S, Hafiz AN, Ali L, Chughtai AS, Memon B, Ahmad A, Hussain S, et al. Methicillin resistant Staphylococcus aureus; a multicentre study. J Pak Med Assoc 2002; 52: 312–315.
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Issue | Vol 6 No 6 (2014) | |
Section | Articles | |
Keywords | ||
Antibiotic therapy Bacterial vaginosis Microbial culture Staphylococcus aureus |
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