Role of neutrophil-lymphocyte-ratio in the mortality of males diagnosed with COVID-19
,
Abstract
Background and Objectives: With this study, for the first time among patients diagnosed with COVID-19, the neutrophil-lymphocyte-ratios of men and women were compared.
Materials and Methods: The study was conducted with 80 patients and the data was gained retrospectively on the electronic documents of the hospital.
Results: The neutrophil-lymphocyte-ratio was statistically significant and higher in the male than the women for all ages and geriatric patients (p<0.05).
Conclusion: The higher neutrophil-lymphocyte-ratio in older males diagnosed with COVID-19 could be a causative reason for the higher mortality rates in men. We hope that these findings would be helpful for further studies.
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29. Liu N, Zhang F, Wei C, Jia Y, Shang Z, Sun L, et al. Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: Gender differences matter. Psychiatry Res 2020;287:112921.
2. Peeri NC, Shrestha N, Rahman MS, Zaki R, Tan Z, Bibi S, et al. The SARS, MERS and novel Coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? Int J Epidemiol 2020; dyaa033. doi: 10.1093/ije/dyaa033.
3. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020;382:1199-1207.
4. Andersen KG, Rambaut A, Lipkin WI, Edward H, Robert FG. The proximal origin of SARS-CoV-2. Nat Med 2020; 26:450-452.
5. Yi Y, Lagniton P, Ye S, Li E, Xu RH. COVID-19: what has been learned and to be learned about the novel coronavirus disease. Int J Biol Sci 2020; 16:1753-1766.
6. Agarwal S, Busse PJ. Innate and adaptive immunosenescence. Ann Allergy Asthma Immunol 2010; 104:183-190.
7. Esme M, Topeli A, Yavuz BB, Akova M. Infections in the elderly critically-Ill patients. Front Med (Lausanne) 2019;6:118.
8. Gomez CR, Nomellini V, Faunce DE, Kovacs EJ. Innate immunity and aging. Exp Gerontol 2008; 43:718-728.
9. Wessels I, Jansen J, Rink L, Uciechowski P. Immunosenescence of poly morphonuclear neutrophils. ScientificWorldJournal 2010;10:145-160.
10. Herndler- Brandstetter D. How aging affects T lymphocyte- mediated immunity. Front Immunol 2013; 4: 296.
11. Rosendahl Huber S, Van Beek J, De Jonge J, Luytjes W, Van Baarle D. T cell responses to viral infections - opportunities for Peptide vaccination. Front Immunol 2014;5: 171.
12. Ge YL, Zhang HF, Zhang Q, Zhu XY, Liu CH, Wang N, et al. Neutrophil-to-lymphocyte ratio in adult community-acquired pneumonia patients correlates with unfavorable clinical outcomes. Clin Lab 2019;65. doi: 10.7754/Clin.Lab.2018.181042.
13. Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis 2020; ciaa248. doi: 10.1093/cid/ciaa248.
14. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395:497-506.
15. Yi Y, Lagniton P, Ye S, Li E, Xu RH. COVID-19: what has been learned and to be learned about the novel coronavirus disease. Int J Biol Sci 2020; 16: 1753-1766.
16. She J, Jiang J, Ye L, Hu L, Bai C, Song Y. 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. Clin Transl Med 2020;9:19.
17. Wong CK, Lam CW, Wu AK, Ip WK, Lee NL, Chan IH, et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol 2004; 136: 95-103.
18. Mahallawi WH, Khabour OF, Zhang Q, Makhdoum HM, Suliman BA. MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile. Cytokine 2018; 104: 8-13.
19. Du Y, Tu L, Zhu P, Mu M, Wang R, Yang P, et al. Clinical features of 85 fatal cases of COVID-19 from Wuhan: A retrospective observational study. Am J Respir Crit Care Med 2020. doi: 10.1164/rccm.202003-0543OC.
20. Zhao S, Cao P, Chong MKC, Gao D, Lou Y, Ran J, et al. COVID-19 and gender-specific difference: Analysis of public surveillance data in Hong Kong and Shenzhen, China, from January 10 to February 15, 2020. Infect Control Hosp Epidemiol 2020;1-2. doi: 10.1017/ice.2020.64.
21. The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. Vital Surveillances: The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) — China, 2020. China CDC Weekly 2020; 2: 113-122.
22. Yang Y, Lu Q, Liu M, Wang Y, Zhang A, Jalali N, et al. Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China. medRxiv 2020. https://doi.org/10.1101/2020.02.10.20021675.
23. Long-Quan L, Tian H, Yong-Qing W, Zheng-Ping W, Yuan L, Tao-Bi H, et al. COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol 2020; 92: 577-583.
24. Ortona E, Pierdominici M, Rider V. Editorial: Sex hormones and gender differences in immune responses. Front Immunol 2019;10:1076.
25. Lin CY, Kwon H, Rangel Rivera GO, Li X, Chung D, Li Z. Sex Differences in using systemic inflammatory markers to prognosticate patients with had and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2018;27:1176-1185.
26. Wu L, Zou S, Wang C, Tan X, Yu M. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in Chinese Han population from Chaoshan region in South China. BMC Cardiovasc Disord 2019; 19: 125.
27. Wenzhong L, Hualan L. COVID-19: Attacks the 1-beta chain of hemoglobin and captures the porphyrin to inhibit human heme metabolism [Internet]. ChemRxiv 2020; 46:07Z.
28. Jaillon S, Berthenet K, Garlanda C. Sexual dimorphism in innate immunity. Clin Rev Allergy Immunol 2019;56:308-321.
29. Liu N, Zhang F, Wei C, Jia Y, Shang Z, Sun L, et al. Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: Gender differences matter. Psychiatry Res 2020;287:112921.
| Files | ||
| Issue | Vol 12 No 3 (2020) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijm.v12i3.3235 | |
| Keywords | ||
| COVID-19; Neutrophils; Lymphocytes | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Belice T, Demir I, Yüksel A. Role of neutrophil-lymphocyte-ratio in the mortality of males diagnosed with COVID-19. Iran J Microbiol. 2020;12(3):194-197.
