An overview of Crimean- Congo Hemorrhagic Fever in Iran
-
Sadegh Chinikar
,
SM Ghiasi
,
A Ghalyanchi- Langeroudi
,
MM Goya
,
MR Shirzadi
,
M Zeinali
,
A Haeri
Abstract
Crimean- Congo Hemorrhagic Fever (CCHF) is a viral zoonotic tick-born disease with a mortality rate of up to 50% in humans. After a short incubation period, the disease is characterized by sudden fever, chills, severe headache, dizziness, back, and abdominal pain. Additional symptoms can include nausea, vomiting, diarrhea, neuropsychiatric, and cardiovascular changes. In severe cases, hemorrhagic manifestations, ranging from petechiae to large areas of ecchymosis develop. The CCHF Virus (CCHFV) is from the genus Nairovirus and family Bunyaviridae. CCHFV is transmitted to humans by the bite of infected tick and by direct contact with blood or tissue from infected humans and livestock. In addition to zoonotic transmission, CCHFV can be spread from person to person and is one of the rare hemorrhagic fever viruses able to cause nosocomial outbreaks in hospitals. CCHF is a public health problem in many regions of the world e.g Eastern Europe, Asia, Middle East, and Africa. The history of CCHF in Iran shows that the disease has been detected in Iran since 1970. From 1970 to 1978 some scientists worked on serology and epidemiology of this disease in humans and livestock in Iran. Since 1999 , establishment of a surveillance and laboratory detection system on viral hemorrhagic fevers particularly on CCHF has had benefits. One of which is the fact that a mortality rate approaching 20% in the year 2000 remarkably dropped to 6% in the year 2007.
Hoogstraal H. The epidemiology of tick- borne crimean- congo hemorrhagic fever in Asia, Europe, and Africa. J Med Entomol 1979; 15 : 307 - 417 .
Chu ma kov M. A new vi r us disease .Cr i mean hemorrhagic fever (in Russian) Nov Med 1979 ;4 : 9 - 11 .
Simpson DI, Knight EM, Courtois G, Williams MC, Weinbren MP, Kibukamusoke JW. Congo virus: A hitherto undescribed virus occurring in africa. I. Human isolations- clinical notes. East Afr Med J 1979 ; 44 : 86 - 92 .
Williams M, Tukei, PM, Lule, M, Mujomba, E, Mukuye, A.Virology: Identification studies. Rep E Afr Virus Res Inst 1966 ; 16: 24 - 26 .
Casals J. Antigenic similarity between the virus causing crimean hemorrhagic fever and congo virus. Proc Soc Exp Biol Med 1969 ; 131: 233 - 236.
Asefi V. Etude clinique de 60 patients atteints d' un syndrome infectieux et hemorrgique en Azerbaidjan (Iran). Iranian J Publ Hlth 1974 ; 3: 140 - 146.
. A r d o i n A , K a r i m i , Y. F o y e r d e p u r p a r a thrombocytopenique en Iran bsans l`azerbaidjan de l`est. Medecine tropicale 1982 ; 42 : 319 - 326.
Saidi S, Casals J, Faghih MA. Crimean hemorrhagic fever-congo (chf- c) virus antibodies in man, and in domestic and small mammals, in Iran. Am J Trop Med Hyg 1975 ; 24 : 353 - 357.
Sureau P, Klein, J.M., Casals, J., Digoutte, J.OP., Salaun, J.J., Piazak, N., Calvo, M.A. Isolation of thogoto, wad medani, wanowrie, and crimean-congo hemorrhagic fever viruses from ticks of domestic animals in iran. Ann Virol (Inst Pasteur ) 1980 ; 131: 185 - 200.
Chinikar S, Mirahmadi, R., Mazaheri, V., Nabeth, P., Saron, M.F, Salehi, P., Hosseini, N., Bouloy, M., Mirazimi, A., Lundkvist, A., Nilsson, M., Mehrabi-tavana, A. A serological survey in suspected human patients of crimean- congo hemorrhagic fever in Iran by determination of IGM specific ELISA method during 2000 - 2004. Arch Ir Med 2005 ; 8 : 52 - 55.
Chinikar S , Ghiasi SM, Ghalyanchi-Langeroudi A, Moradi M. Situation of Crimean-Congo Hemorrhagic Fever in Iran and Region Countries. Arbo-zoonet Newsletter 2009; 02: 7.
Chinikar S, Goya MM, Shirzadi MR, et al. Surveillance and laboratory detection system of crimean-congo haemorrhagic fever in Iran. Transbound Emerg Dis 2008 ; 55 : 200 - 204.
Chinikar S, Persson SM, Johansson M, et al. Genetic analysis of crimean-congo hemorrhagic fever virus in Iran. J Med Virol 2004 ; 73 : 404 - 411.
Garcia S, Chinikar S, Coudrier D, et al. Evaluation of a crimean-congo hemorrhagic fever virus recombinant antigen expressed by semliki forest suicide virus for igm and igg antibody detection in human and animal sera collected in Iran. J Clin Virol 2006 ; 35 : 154 - 159.
Chinikar S, Fayaz, A., Mirahmadi, R., Mazaheri, V., Mathiot, C., Saron, M.F. The specific serological investigation of suspected human and domestic animals to have crimean- congo hemorrhagic fever in various part of iran using elisa techniques. Hakim J (in persian) 2002 ; 4 :294 - 300.
Chinikar S. Seroepidemiology of crimean-congo haemorrhagic fever in human and domestic animals in Iran by analyzing the quantities of specific IGM and IGG against the virus of the disease by ELISA method. J of Veterinary Organization (in persian) 2003 ; 3 : 69 - 73.
Donets MA, Chumakov MP, Korolev MB, Rubin SG. Physicochemical characteristics, morphology and morphogenesis of virions of the causative agent of Crimean hemorrhagic fever. Intervirology 1977 ; 8 : 294 - 308.
Ellis DS, Southee T, Lloyd G, et al. Congo/crimean haemorrhagic fever virus from Iraq 1979: I. Morphology in bhk21 cells. Arch Virol 1981 ; 70 : 189 - 198 .
Martin ML, Lindsey- Regnery H, Sasso DR, McCormick JB, Palmer E. Distinction between bunyaviridae genera by surface structure and comparison with hantaan virus using negative stain electron microscopy. Arch Virol 1985 ; 86 : 17 - 28.
Fields BN, Knipe DM, Howley PM. Fields virology.5th edn. Philadelphia ; London: Wolters Kluwer Health / Lippincott Williams & Wilkins 2007.
Marriott AC, Polyzoni T, Antoniadis A, Nuttall PA. Detection of human antibodies to crimean-congo haemorrhagic fever virus using expressed viral nucleocapsid protein. J Gen Virol 1994 ; 75 (Pt 9): 2157 - 2161.
Marriott AC, Nuttall PA. Comparison of the sRNA segments and nucleoprotein sequences of crimean-congo hemorrhagic fever, hazara, and dugbe viruses. Virology 1992 ; 189 : 795 - 799.
Camicas JL, Cornet JP, Gonzalez JP, Wilson ML, Adam F, Zeller HG. (crimean-congo hemorrhagic fever in Senegal. Latest data on the ecology of the CCHF virus). Bull Soc Pathol Exot 1994 ; 87: 11 - 16.
Suleiman MN, Muscat-Baron JM, Harries JR, et al. Congo/ crimean haemorrhagic fever in Dubai. An outbreak at the Rashid hospital. Lancet 1980 ; 2 : 939 - 941.
van Eeden PJ, van Eeden SF, Joubert JR, King JB, van de Wal BW, Michell WL. A nosocomial outbreak of crimean-congo haemorrhagic fever at Tygerberg hospital. Part ii. Management of patients. S Afr Med J 1985 ; 68 :718 - 721.
Fisher-Hoch SP, Khan JA, Rehman S, Mirza S, Khurshid M, McCormick JB. Crimean congo- haemorrhagic fever treated with oral ribavirin. Lancet 1995 ; 346 : 472 - 475.
Gonzalez JP, Camicas JL, Cornet JP, Faye O, Wilson ML. Sexual and transovarian transmission of crimean- congo haemorrhagic fever virus in hyalomma truncatum ticks. Res Virol 1992 ; 143 : 23 - 28.
Logan TM, Linthicum KJ, Bailey CL, Watts DM, Moulton JR. Experimental transmission of crimean-congo hemorrhagic fever virus by hyalomma truncatum koch. Am J Trop Med Hyg 1989 ; 40 : 207 - 212.
Shepherd AJ, Swanepoel R, Shepherd SP, Leman PA, Mathee O. Viraemic transmission of crimean-congo haemorrhagic fever virus to ticks. Epidemiol Infect 1991;106 : 373 - 382.
Sanchez AJ, Vincent MJ, Nichol ST. Characterization of the glycoproteins of crimean-congo hemorrhagic fever virus. J Virol 2002 ; 76 : 7263 - 7275.
Gear JH. Hemorrhagic fevers, with special reference to recent outbreaks in southern africa. Rev Infect Dis 1979 ; 1:571 - 591.
Ergonul O. Crimean-congo haemorrhagic fever.Lancet Infect Dis 2006 ; 6: 203 - 214.
Swanepoel R, Struthers JK, Shepherd AJ, McGillivray GM, Nel MJ, Jupp PG. Crimean-congo hemorrhagic fever in South Africa. Am J Trop Med Hyg 1983 ; 32 : 1407 -1415 .
Swanepoel R, Shepherd AJ, Leman PA, et al. Epidemiologic and clinical features of crimean-congo hemorrhagic fever in southern africa. Am J Trop Med Hyg 1987; 36 : 120 - 132.
Swanepoel R, Gill DE, Shepherd AJ, Leman PA, Mynhardt JH, Harvey S. The clinical pathology of crimean- congo hemorrhagic fever. Rev Infect Dis 1989 ; 11 Suppl 4 : S 794 - 800.
Whitehouse CA. Crimean-congo hemorrhagic fever.Antiviral Res 2004 ; 64 : 145 -160.
Papa A, Bino S, Velo E, Harxhi A, Kota M, Antoniadis A. Cytokine levels in crimean-congo hemorrhagic fever. J Clin Virol 2006 ; 36 : 272 - 276.
Schwarz TF, Nsanze H, Longson M, et al. Polymerase chain reaction for diagnosis and identification of distinct variants of crimean- congo hemorrhagic fever virus in the United Arab Emirates. Am J Trop Med Hyg 1996 ; 55: 190 - 196.
Schwarz TF, Nsanze H, Ameen AM. Clinical features of crimean- congo haemorrhagic fever in the united Arab Emirates. Infection 1997 ; 25 : 364 - 367.
Geisbert TW, Jahrling PB. Exotic emerging viral diseases: Progress and challenges. Nat Med 2004 ; 10 : S 110 - 121.
Feldmann H, Jones S, Klenk HD, Schnittler HJ. Ebola virus: From discovery to vaccine. Nat Rev Immunol 2003 ; 3: 677 - 685.
Nabeth P, Thior M, Faye O, Simon F. Human crimean- congo hemorrhagic fever, senegal. Emerg Infect Dis 2004 ; 10 : 1881 - 1882.
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| CCHF Arboviruses Iran | ||
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