Comparing the effect of two types of silver nano-crystalline dressings (acticoat and agcoat) in the treatment of full thickness burn wound
-
Faranak Alinejad
,
Mahnoush Momeni
,
Mohammad Javad Fatemi
,
Mostafa Dahmardehei
,
Soheila Naderi
,
Mohammad Reza Akhoondinasab
,
Masoume Zayedly
,
Omid Mahboubi
,
Hossein Rahbar
Abstract
Background and Objectives: This study was conducted to compare the effect of acticoat and agcoat dressing (2 types of silver nano-crystalline dressings) in the treatment of burn wounds. Infection is one of the most important causes of death in patients with major burn. Despite using different prevention methods, including prophylaxis antibiotics with broad-spectrum antibiotics, no method has been found to prevent this dangerous complication for burn patients. Topical silver sulfadiazine is one of the best topical antibiotics in infection control of burn wounds, and other forms of AG dressings are also useful. Their advantages are slow releasing, further-half-life, less frequent dressing change, and less pain during replacement.
Materials and Methods: In this study, 30 patients with infected full thickness burn wound were selected. The patients’ age range was 18-85 years, with the mean age of 39.7-17.27. Every patient's wound was divided into 2 parts randomly, one part was dressed with agcoat and the other with acticoat. Sampling of the 2 parts was done before dressing and after the third and seventh day of dressing.
Results: The positive outcome of the first day culturing before silver dressing was 80% and 76.7% for agcoat and acticoat, respectively. However, on the third day, it decreased to 30% and 33.3%, respectively. On the seventh day, it further decreased to 20% in both groups, and the percentage of bacterial growth reduction was not significant.
Conclusion: Based on the results of this study, silver agcoat dressing was as effective as acticoat dressing in preventing burn wound infection.
Xuehui, Zhu, Chen Yuquan, and Zhang Hunian. "Causes of burn-out of articulated phase breaker cable and its prevention measures [J]." Electric Railway 4 (2007): 32-35.
Bloemsma, G. C., et al. "Mortality and causes of death in a burn centre." Burns 34.8 (2008): 1103-1107.
Khorasani GA, Hosseinimehr SJ. Epidemiology and Mortality of Burns in the North of Iran. Research journal of Biological sciences 2007; 2: 519-22.
Lin TM, Wang KH, Lai CS, Lin SD. Epidemiology of pediatric burn in southern Taiwan. Burns 2005; 31: 182-7.
Anlatici R, Ozerdem OR, Dalay C, Kesiktas E, Acarturk S, Seydaoglu G. A retrospective analysis of 1083 Turkish patients with serious burns, Burns 2002; 28: 231-7.
Kiani Z, Seddigh A. A survey on 30 months electrical burns in Shiraz University of Medical Sciences Burn Hospital. Burns 2008; 34: 111-3.
Panjeshahin MR, Lari AR, Talei AR, Shamsnia J, Alaghehbandan R. Epidemiology and mortality of burns in the south west of Iran. Burns 2001; 27:2l9-26.
Ansari-Lari M, Askarian M. Epidemiology of burns presenting to an emergency department in Shiraz, South Iran. Burns 2003; 29: 579-81.
Maghsoudi H, Samnia N. Etiology and outcome of pediatric burns in Tabriz, Iran. Burns 2005; 31: 721-5.
Nursal TZ, Yildirm S, Tarim A, Caliskan K, Ezer A, Noyan T. Burn in southern turkey: Electrical burns remain a major problem. 2003; 24: 309-14.
Vindenes H, Bjerknes R. Microbial colonization of large wounds. Burns 1995; 21: 575-9.
Rutan RL. Physiologic response to cutaneous burn injury. In: Carrougher GJ, editor. Burn care and therapy. St Louis: Mosby; 1998. P. 1-33.
Barret, Juan P., and David N. Herndon. "Effects of burn wound excision on bacterial colonization and invasion." Plastic and reconstructive surgery 111.2 (2003): 744-50.
Albrecht, Michael A., et al. "Impact of Acinetobacter infection on the mortality of burn patients." Journal of the American College of Surgeons 203.4 (2006): 546-550.
Brusselaers, Nele, et al. "Severe burn injury in Europe: a systematic review of the incidence, etiology, morbidity, and mortality." Critical care 14.5 (2010): R188.
O'grady, Naomi P., et al. "Guidelines for the prevention of intravascular catheter-related infections." Clinical infectious diseases 52.9 (2011): e162-e193.
Atiyeh, Bishara S., et al. "Effect of silver on burn wound infection control and healing: review of the literature." burns 33.2 (2007): 139-148.
Fong, Joy, and Fiona Wood. "Nanocrystalline silver dressings in wound management: a review." international Journal of Nanomedicine 1.4 (2006): 441.
Prabhu, Sukumaran, and Eldho K. Poulose. "Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects." International Nano Letters 2.1 (2012): 32.
Atiyeh, Bishara S., et al. "Effect of silver on burn wound infection control and healing: review of the literature." burns 33.2 (2007): 139-148.
Kim JS, Kuk E, Yu KN, Kim J-H, Park SJ, Lee HJ. Antimicrobial effects of silver nanoparticles. Nanomed-Nanotechnol. 2007; 3: 95-101.
Kapoor S, Lawless D, Kennepohl P, Meisel D, Serpone N. Reduction and aggregation of silver ions in aqueous gelatin solutions. Langmuir. 1994; 10:3018-22.
Moyer CA, Brentano L, Gravens DL, Margraf HW, Monafo WW. Treatment of large human burns with 0.5% silver nitrate solution. Arch Surg. 1965; 90:812-67.
Gurunathan S, Kalishwaralal K, Vaidyanathan R, Venkataraman D, Pandian SRK, Muniyandi J, et al. Biosynthesis, purification and characterization of silver nanoparticles using Escherichia coli. Colloidsand Surfaces: Biointerfaces. 2009; 74: 328-35.
Jafarnejad B, Karimi H, Hafezi F, Fatemi M. J. ,Zare Mehrjardi A, Saber M. Comparison of Silver Serum Levels and Acute Toxic Effect of Nano-Silver on Hystopathology of Organs (Lungs, Liver, Kidney, Brain) in Two Types of AgiCoat and Acticoat Dressings on Second -Degree Deep Burn in Rat. Iran Journal of Surgery25 (1). 39-48, 2017
| Files | ||
| Issue | Vol 10 No 6 (2018) | |
| Section | Original Article(s) | |
| Keywords | ||
| Burns Infection Silver nano-crystalline dressing | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
