Short Communication

Seroprevalence of hepatitis B, C and D viral among hemodialysis patients in Tehran

Abstract

Background and Objectives: Different studies show that the prevalence of hepatitis viruses in hemodialysis (HD) patients is much greater than general population. It is important to be aware of local prevalence data, in order to control infections and prevention of nosocomial transmission. The aim of this cross-sectional study was to investigate the seroprevalence of hepatitis B, C, and D viral infections among HD patients.
Materials and Methods: During 2016, a cross-sectional study was conducted in Tehran, among 360 HD patients from 5 hemodialysis centers. All HBsAg positive subjects were screened for Hepatitis B surface Ag (HBsAg), Hepatitis C virus Ab (HCVAb) and Hepatitis D virus antibody (HDVAb), using specific enzyme linked immunoassay.
Results: 360 patients were involved including 213 males (59.17%) and 147 females (40.83%). The mean age in current study was 53.43 years. HBV positive (HBsAg positive) was found in 1.39% of patients, HCVAb in 3.06%, whereas no HDV positive patient was diagnosed. In HD, duration of 1-5 years has the highest frequency rate.
Conclusion: Prevalence of HBV, HCV and HDV in hemodialysis patients seems low in Tehran province. Due to higher prevalence of HCV, it is recommended to check the patients for anti-HCV Ab before admission to the centers.

Oguchi H, Miyasaka M, Tokunaga S, Hora K, Ichikawa S, Ochi T, et al. Hepatitis virus infection (HBV and HCV) in eleven Japanese hemodialysis units. Clin Nephrol 1992;38:36-43.

Alavian SM, Bagheri-Lankari K, Mahdavi-Mazdeh M, Nourozi S. Hepatitis B and C in dialysis units in Iran: changing the epidemiology. Hemodial Int 2008;12:378-382.

Elamin S, Abu-Aisha H. Prevention of hepatitis B virus and hepatitis C virus transmission in hemodialysis centers: review of current international recommendations. Arab J Nephrol Transplant 2011;4(1):35-47.

Kane M. Global programme for control of hepatitis B infection. Vaccine 1995;13:S47-S9.

Esmaeilzadeh A, Goshayeshi L, Bahari A, Ganji A, Mozaffari HM. Regional distribution of hepatitis delta virus in Iran: a Systematic literature review. Govaresh 2017;22(1):57-63.

Department of Health and Social Security: Report of advisory committee on hepatitis and treatment of chronic renal failure 1970-1972. Londen, DHSS, 1972.

Mohammed AA, Enan KA, Khair OM, Hussien MO, El Hussein ARM, Elkhidir IM. Prevalence of occult hepatitis B virus (HBV) infections in haemodialysis patients in Khartoum State, Sudan from 2012 to 2014. J Med Lab Diagn 2015;6:22-26.

Edey M, Barraclough K, Johnson DW. Review article: Hepatitis B and dialysis. Nephrology 2010;15:137-145.

Sułowicz W, Radziszewski A, Chowaniec E. Hepatitis C virus infection in dialysis patients. Hemodial Int 2007;11:286-295.

Druwe P, Michielsen P, Ramon A, De Broe M. Hepatitis C and nephrology. Nephrol Dial Transpl 1994;9:230-237.

Schneeberger PM, Keur I, van Loon AM, Mortier D, de Coul KO, Verschuuren-van Haperen A, et al. The prevalence and incidence of hepatitis C virus infections among dialysis patients in the Netherlands: a nationwide prospective study. J Infect Dis 2000;182:1291-1299.

Handajani R, Lusida M, Darmadi S, Adi P, Ishido S, Katayama Y, et al. Differential prevalence of hepatitis C virus subtypes in healthy blood donors, patients on maintenance hemodialysis, and patients with hepatocellular carcinoma in Surabaya, Indonesia. J Clin Microbiol 1996;34:2875-2880.

Tokars JI, Miller ER, Alter MJ, Arduino MJ. National surveillance of dialysis associated diseases in the United States, 1995. ASAIO J 1998;44:98-107.

Keur I, Schneeberger P, Van der Graaf Y, Vos J, Van Dijk W, Van Doorn L-J. Risk factors for HCV infection in two haemodialysis units in the Netherlands. Neth J Med 1997;50:97-101.

Hinrichsen H, Leimenstoll G, Stegen G, Schrader H, Fölsch U, Schmidt W. Prevalence and risk factors of hepatitis C virus infection in haemodialysis patients: a multicentre study in 2796 patients. Gut 2002;51:429-433.

Petrosillo N, Gilli P, Serraino D, Dentico P, Mele A, Ragni P, et al. Prevalence of infected patients and understaffing have a role in hepatitis C virus transmission in dialysis. Am J Kidney Dis 2001;37:1004-1010.

Ansar M, Kooloobandi A. Prevalence of hepatitis C virus infection in thalassemia and haemodialysis patients in north Iran-Rasht. J Viral Hepat 2002;9:390-392.

Alavian S, Tabatabaei S, Lankarani K. Epidemiology of HCV infection among thalassemia patients in eastern Mediterranean countries: a quantitative review of literature. Iran Red Crescent Med J 2010;2010:365-376.

Alavian SM, Einollahi B, Hajarizadeh B, Bakhtiari S, Nafar M, Ahrabi S. Prevalence of hepatitis C virus infection and related risk factors among Iranian haemodialysis patients. Nephrology 2003;8:256-260.

Husa P, Linhartova A, Nemecek V, Husova L. Hepatitis D. Acta Virol 2005;49:219.

Ghadir MR, Belbasi M, Heidari A, Sarkeshikian SS, Kabiri A, Ghanooni AH, Iranikhah A, Vaez-Javadi M, Alavian SM. Prevalence of hepatitis d virus infection among hepatitis D virus infected patients in qom province, center of Iran. Hepat Mon 2012;2012:205-208.

Rizzetto M, Alavian SM. Hepatitis delta: the rediscovery. Clin Liver Dis 2013;17:475-487.

Delić D, Gotić M, Oštrić V, Fridman V, Nikolić P, Jemuović L, et al. Epidemiology of hepatitis D virus (delta) infection in Yugoslavia. Liver Int 1993;13:302-304.

Martins MA, França E, Matos JC, Goulart E. Post-discharge surveillance of children and adolescents treated for surgical site infections at a university hospital in Belo Horizonte, Minas Gerais State, Brazil. Cad Saude Publica 2008;24:1033-1041.

Alavian SM, Kabir A, Ahmadi AB, Lankarani KB, Shahbabaie MA, Ahmadzad-Asl M. Hepatitis C infection in hemodialysis patients in Iran: a systematic review. Hemodial Int 2010;14:253-262.

Mashragi F, Bernstein RS, Al-Mazroa M, Al-Tawfiq JA, Filemban S, Assiri A, et al. HIV transmission at a Saudi Arabia hemodialysis unit. Clin Infect Dis 2014;59:897-902.

Su Y, Yan R, Duan Z, Norris JL, Wang L, Jiang Y, et al. Prevalence and risk factors of hepatitis C and B virus infections in hemodialysis patients and their spouses: A multicenter study in Beijing, China. J Med Virol 2013;85:425-432.

Bahri F, Kheirabad AK, Ghasemzadeh I, Shoja S, Gouklani H. Hepatitis Viruses B and D and Human Immunodeficiency Virus infections in hemodialysis patients in the south of Iran: prevalence and genotypes. Hepat Mon 2016;16(1): e32971.

Zahedi MJ, Moghaddam SD, Alavian SM, Dalili M. Seroprevalence of hepatitis viruses B, C, D and HIV infection among hemodialysis patients in Kerman Province, South-East Iran. Hepat Mon 2012;12:339-343.(5):339.

Voiculescu M, Iliescu L, Ionescu C, Micu L, Ismail G, Zilisteanu D, et al. A cross-sectional epidemiological study of HBV, HCV, HDV and HEV prevalence in the SubCarpathian and South-Eastern regions of Romania. J Gastrointestin Liver Dis 2010;19:43-48.

Sartor C, Brunet P, Simon S, Tamalet C, Berland Y, Drancourt M. Transmission of hepatitis C virus between hemodialysis patients sharing the same machine. Infect Control Hosp Epidemiol 2004;25:609-611.

Mohammad A, Aliasghar S, Afchangi A. Hepatitis B and hepatitis C in multi-center hemodialysis patients in Tehran. Indian J Appl Res 2016;5:417-418.

Kheirabad AK, Bahri F, Kargar M, Ghasemzadeh I. Hepatitis C and G Virus infection prevalence among hemodialysis patients and associated risk factors in the Hormozgan province of southern Iran. Hepat Mon 2016;16(10):e40375.

Hosseini-Moghaddam SM, Afshar-Imani A, Rizzetto M, Alavian SM. Viral hepatitis D among hemodialysis patients: a worldwide underestimated problem. Hepat Mon 2009;9:305-311.

El Hady HA, Yassein YS, Tawfek AR, Elsayed AF, Dewedar MK. Study of epidemiological features of hepatitis D virus infection in HBsAg-positive chronic hemodialysis patients. Menoufia Med J 2016;29(1):37-43.

Alavian SM. Hepatitis D is a forgotten problem in hemodialysis patients in the world. Hepat Mon 2008;8(1):9-10.

Hsieh TH, Liu CJ, Chen DS, Chen PJ. Natural course and treatment of hepatitis D virus infection. J Formos Med Assoc 2006;105:869-881.

Files
IssueVol 9 No 3 (2017) QRcode
SectionShort Communication
Keywords
Seroprevalence HBV HCV HDV Hemodialysis

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Yadegarynia D, Hatami H, Roodsari S, Arab-Mazar Z. Seroprevalence of hepatitis B, C and D viral among hemodialysis patients in Tehran. Iran J Microbiol. 2017;9(3):195-199.