Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 17 4 2025 07 29 593 599 Yousra Sbibih Laboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco; Laboratory of Microbiology, Mohammed VI University Hospital, Oujda, Morocco Abderrazak Saddari Laboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco; Laboratory of Microbiology, Mohammed VI University Hospital, Oujda, Morocco Ilham Alla Laboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco; Laboratory of Microbiology, Mohammed VI University Hospital, Oujda, Morocco Said Ezrari Laboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco Elmostapha Benaissa Department of Bacteriology, Mohammed V Teaching Military Hospital, Rabat, Morocco; Epidemiology and Bacterial Resistance Research Team/BIO-INOVA Centre, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco Yassine Lahlou Department of Bacteriology, Mohammed V Teaching Military Hospital, Rabat, Morocco; Epidemiology and Bacterial Resistance Research Team/BIO-INOVA Centre, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco Mostafa Elouennass Department of Bacteriology, Mohammed V Teaching Military Hospital, Rabat, Morocco; Epidemiology and Bacterial Resistance Research Team/BIO-INOVA Centre, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco Adil Maleb Laboratory of Microbiology, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco; Laboratory of Microbiology, Mohammed VI University Hospital, Oujda, Morocco; Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed the First, Oujda, Morocco 2024 11 25 2025 05 17 Background and Objectives: Helicobacter pylori, identified in 1982, remains a major cause of gastric infections. Despite extensive research, an ideal treatment regimen for its eradication is yet to be determined, with antibiotic resistance posing a significant challenge. This study, conducted at Mohammed VI University Hospital, aimed to evaluate and compare the effectiveness of different therapeutic protocols for H. pylori eradication. Materials and Methods: This 13-month retrospective descriptive study was conducted at the Microbiology Laboratory of Mohammed VI University Hospital in Oujda, Morocco, to evaluate patients suspected of H. pylori infection using the urea breath test. Results: A total of 190 patients were included, with an overall eradication rate of 73%. Three therapeutic protocols were tested, and bismuth concomitant therapy showed the highest eradication rate at 82%, outperforming the other regimens. Conclusion: These findings highlight the importance of combining antimicrobial agents with antisecretory treatments to enhance eradication outcomes. The study also emphasizes the need for novel treatment strategies, particularly in light of rising antibiotic resistance. Vonoprazan-based regimens appear to offer a promising alternative, especially in the absence of antibiotic sensitivity testing. Future research should focus on optimizing treatment protocols while preserving beneficial gut flora. https://ijm.tums.ac.ir/index.php/ijm/article/view/5155 https://ijm.tums.ac.ir/index.php/ijm/article/download/5155/1802