Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 6 2 2014 04 15 84 86 EN Mohammadsaeed Sasan Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran. Nahid Donyadide Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran. Emran Askari Students Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. Mahboobeh Naderi-Nasab Department of Microbiology, Central Laboratory, Imam Reza Teaching Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. 2015 10 16 Background and Objective: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is increasingly reported worldwide. We aimed to determine the frequency of invasive CA-MRSA in children admitted to the pediatric wards of Imam Reza and Ghaem hospitals of Mashhad, Iran. Materials and Methods: In this retrospective study, data regarding S. aureus isolates from pediatric patients’ sterile body sites (i.e. blood‚ joint, bone and lymph node aspiration) were retrieved in a time period from March 2006 to March 2012. Disc diffusion data was analyzed to determine the resistance pattern of the isolates, and differentiation between community- acquired and nosocomial S. aureus was done according to CDC guidelines. Results: Twenty three invasive community-acquired S. aureus isolates from sterile body sites were identified, of which seventeen (74%) were CA-MRSA. The CA-MRSA isolates showed high frequency of resistance to non-β-lactam antibiotics (71% to erythromycin‚ 53% to co-trimoxazole, 44% to gentamicin and 36% to ciprofloxacin). Conclusion: In this study, the majority of invasive community-acquired S. aureus isolates were found to be CA-MRSA. Therefore, we recommend that primary treatment should be with antibiotics such as clindamycin, vancomycin, linezolid or daptomycin for any invasive infection suspected to be caused by S. aureus in these two hospitals. https://ijm.tums.ac.ir/index.php/ijm/article/view/447 https://ijm.tums.ac.ir/index.php/ijm/article/download/447/224