Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 16 1 2024 02 12 155 158 Vaanya Kaushik Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India Ruchee Khanna Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India Vinay Khanna Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India Muralidhar Varma Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India 2023 10 07 2023 11 17 We present a case of a 43-year-old immunocompromised female patient diagnosed with disseminated histoplasmosis on bone marrow examination, at clinical laboratory of Kasturba Hospital, Manipal, Karnataka, India. The patient, presenting with symptoms like weight loss, appetite loss, and pancytopenia, underwent bone marrow aspiration and biopsy. The bone marrow studies revealed HIV-associated changes and the yeast form of Histoplasma capsulatum, confirming disseminated histoplasmosis. Bone marrow examination is highlighted as a diagnostic tool with significant sensitivity in such cases. The report stresses on the importance of awareness and early diagnosis of histoplasmosis in immunocompromised patients, given its potential lethality and the need for timely therapeutic intervention for better prognosis. https://ijm.tums.ac.ir/index.php/ijm/article/view/4434 https://ijm.tums.ac.ir/index.php/ijm/article/download/4434/1650