Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 15 6 2023 11 20 821 825 Sagila Gangadharan Department of Microbiology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India Swapna Raveendranath Department of Microbiology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India 2023 07 04 2023 10 14 Cryptococcosis, a relatively uncommon infection in cancer patients is often associated with delayed diagnosis and high fatality rate due to its highly heterogeneous and protean manifestations. Early recognition and initiation of appropriate antifungal therapy might have a favourable outcome in such cases. Here we report three cases of Cryptococcosis among cancer patients in a tertiary care cancer centre in South India. All three patients were males of different ages at presentation with immunosuppression in the form of solid organ or hematologic malignancy and were using immunosuppressive medications like steroids or chemotherapeutic agents. They presented with cryptococcemia and cryptococcal meningitis. Patients with microbiologically proven cryptococcosis had poor outcome in this subgroup of patients. https://ijm.tums.ac.ir/index.php/ijm/article/view/4300 https://ijm.tums.ac.ir/index.php/ijm/article/download/4300/1630