Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 14 5 2022 10 22 765 769 Maryam Sarkardeh Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Ali Ahmadabadi Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Sadrzadeh Department of Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Javad Koushki Department of Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Amir Esmaeili Department of Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Sima Davoodi Department of Dermatology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Mostafa Izanlu Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran 2022 03 08 2022 07 30 Necrotizing fasciitis and myonecrosis caused by Escherichia coli is an extremely uncommon infection with a high mortality. We present a case of 41-year-old man with no history of underlying disease one week after covid-19 infection, who was admitted with symptoms of Fournier's gangrene and then E. coli-induced monomicrobial necrotizing fasciitis. https://ijm.tums.ac.ir/index.php/ijm/article/view/3593 https://ijm.tums.ac.ir/index.php/ijm/article/download/3593/1516