Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 14 3 2022 06 13 276 284 EN Kamran Lankarani Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran Maryam Akbari Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran Reza Tabrizi Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran; Clinical Research Development Unit of Vali Asr Hospital, Fasa University of Medical Sciences, Fasa, Iran Mohebat Vali Department of Epidemiology, Shiraz University of Medical Sciences, Shiraz, Iran Eghbal Sekhavati Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran Seyed Taghi Heydari Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran Hossein Khodadadi Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Fariba Ahmadizar Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. 2021 10 08 2022 03 18 Background and Objectives: Candida auris (C. auris) is the first fungal pathogen considered a global health threat. Because, C. auris is associated with multidrug resistance and associated diseases such as diabetes, sepsis, lung and kidney disease. This study investigated the prevalence and mortality of C. auris infection during Covid-19 pandemic. Materials and Methods: Databases were searched for peer-reviewed articles published in the English language up to Jan 18, 2022. Heterogeneity across studies was evaluated using Cochrane’s Q test and the I2 index. The pooled point prevalences and their corresponding 95% confidence intervals (CIs) were estimated usingthe random-effects model. Results: In our meta-analysis, 11 eligible articles were included. The total pooled prevalence estimation of C. auris infection among COVID-19 patients was 13% (95% CI: 8%, 19%). The estimated pooled mortality rate of C. auris infection was 37% (95% CI: 15%, 61%). In terms of specific conditions, the pooled risk of mortality was higher in people with diabetes 65% (95% CI: 0.45%, 83%), in cases with >21 days admission inintensive care unit (ICU) 44% (95% CI: 21%, 0.68%), and after receiving steroids 43% (95% CI: 18%, 69%). Conclusion: Our study highlights the high prevalence rate of C. auris infection, particularly among people with a history of metabolic disorders. https://ijm.tums.ac.ir/index.php/ijm/article/view/3355 https://ijm.tums.ac.ir/index.php/ijm/article/download/3355/1453