Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 13 5 2021 10 08 617 623 Ranjana Rohilla Department of Microbiology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, India Dimple Raina Department of Microbiology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, India Malvika Singh Department of Microbiology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, India Ajay Pandita Department of Community Medicine, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, India Shiwang Patwal Department of Microbiology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, India 2021 06 03 2021 08 27 Background and Objectives: Sphingomonas paucimobilis is an opportunistic pathogen and was rarely encountered in clinical specimens previously. This study aimed to investigate the clinical features, associated co-morbidities, and antimicrobial susceptibility patterns of S. paucimobilis infection in a tertiary hospital in Uttarakhand. Materials and Methods: S. paucimobilis isolates cultured from various sections of hospital and OPDs were identified and analyzed for their antibiograms in the microbiology laboratory for a duration of one year from January 2020 to December 2020. Results: S. paucimobilis was isolated from 49 samples (0.01%) out of 3792 samples processed in VITEK 2 Compact automated ID/AST instrument. The maximum number of isolates were obtained from urine samples (31%), followed by blood (24%). Septicemia (41%), meningitis (17%), lower respiratory tract infections and ventilator associated pneumonia (14%) constituted a major portion of infections caused by this organism. Diabetes mellitus (22%) and steroid usage (16%) were major associated co-morbid conditions. Third and Fourth generation cephalosporins like ceftriaxone (81%) and cefepime (86%) were found to be the most susceptible drugs whereas 61% of isolates were resistant to colistin. Conclusion: This organism is an up-and-coming pathogen and should not be simply labeled as a contaminant. Although the organism is not grossly virulent and still might not be associated with serious life-threatening infections; however their evolving resistance patterns and increased spectrum of infections should be seriously taken into account. https://ijm.tums.ac.ir/index.php/ijm/article/view/3177 https://ijm.tums.ac.ir/index.php/ijm/article/download/3177/1386