Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 13 4 2021 08 11 427 433 EN Zahra Heydarifard Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Jila Yavarian Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Somayeh Shatizadeh Malekshahi Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Sevrin Zadheidar Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Talat Mokhtari-Azad Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Nazanin Zahra Shafiei-Jandaghi Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2021 02 23 2021 06 26 Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a newly emerged virus which belongs to Coronaviridae family within the betacoronavirus genus. Previous reports demonstrated that other betacoronaviruses were responsible for adverse outcomes during pregnancy in human. Due to inadequate data, the consequences of a SARS-CoV-2 infection during pregnancy is still a public health concern in the second year of SARS-CoV-2 circulation in human population. Herein, we aimed to review the probable risk of intrauterine vertical transmission of SARS-CoV-2 infection to the fetus, its adverse outcomes during pregnancy for both mother and the fetus and maternal risk factors which affect the severity Coronavirus disease 2019 (COVID-19. https://ijm.tums.ac.ir/index.php/ijm/article/view/3004 https://ijm.tums.ac.ir/index.php/ijm/article/download/3004/1362