Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 13 3 2021 06 05 257 265 Rahimeh Sanikhani Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran Mohammad Moeinirad Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Fereshteh Shahcheraghi Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran Arezou Lari Department of Systems Biomedicine, Pasteur Institute of Iran, Tehran, Iran Sepideh Fereshteh Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran Amin Sepehr Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran Afsaneh Salimi Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran Farzad Badmasti Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran 2020 07 12 2021 04 14 Classical (CKp) and hypervirulent (hvKp) Klebsiella pneumoniae are two different circulating pathotypes. The aim of this study was to assess the prevalence, epidemiology and molecular relatedness of hvKps using a systemic review and meta-analysis. The data extracted from Medline, Embase, and Web of Science and finally 14 studies met the eligible criteria. To combine prevalence proportions of all studies, we performed the metaprop command embedded in the Meta package software. Totally, of 1814 K. pneumoniae isolates, 21.7% (394/1814) were hvKp. The molecular typing showed that all hvKp isolates were grouped into 50 different sequence types (STs) of them ST23, ST11, ST65 and ST86 were common. K1, K2 and K64 were dominant capsule serotypes that strongly related to ST23, ST65 and ST11, respectively. It seems that clonal group 23 (CG23) is associated with liver abscess and CG11 related to various clinical sources. https://ijm.tums.ac.ir/index.php/ijm/article/view/2705 https://ijm.tums.ac.ir/index.php/ijm/article/download/2705/1342