Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 11 3 2019 07 25 206 211 Andy Darma Department of Child Health, Dr. Soetomo Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia Bagus Samsu Tri Nugroho Department of Child Health, Dr. Soetomo Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia Vinny Yoanna Department of Child Health, Dr. Soetomo Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia Indah Sulistyani Department of Child Health, Dr. Soetomo Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia Alpha Fardah Athiyyah Department of Child Health, Dr. Soetomo Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia Reza Gunadi Ranuh Department of Child Health, Dr. Soetomo Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia Subijanto Marto Sudarmo Department of Child Health, Dr. Soetomo Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia 2019 06 02 2019 06 06 Background and Objectives: Various non-invasive diagnostic tests are available for the detection of Helicobacter pylori infection. The aim of this study was to compare the sensitivity and specificity of HpSA, salivary IgG, serum IgG, and serum IgM to those of endoscopic-biopsy as the gold standard for the diagnosis of H. pylori infection. Materials and Methods: This is a cross-sectional study performed among pediatric patients at Dr. Soetomo General Hospital (Surabaya, Indonesia). Fecal, blood, and saliva samples were collected from all subjects. The results of the HpSA, salivary IgG, serum IgG, and serum IgM tests were compared to the results of endoscopic-biopsy as the gold standard. Results: Of the 37 study participants, H. pylori infection was confirmed in 5 (13.33%) with serum IgG, 23 (63.33%) with serum IgM, 15 (40%) with HpSA, and 26 (70.97%) with salivary IgG. The salivary IgG enzyme-linked immunosorbent assay (ELISA) was the only diagnostic test with significantly different results, as compared to biopsy (p = 0.017). Conclusion: The results of this study showed that HpSA, salivary IgG, and serum IgG and IgM were not sufficient to replace endoscopic-biopsy as the gold standard for the diagnosis of H. pylori infection. https://ijm.tums.ac.ir/index.php/ijm/article/view/2197 https://ijm.tums.ac.ir/index.php/ijm/article/download/2197/1174