Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 11 3 2019 07 26 255 259 David Perdanakusuma Department of Plastic Reconstructive and Aesthetic Surgery, School of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, Indonesia Lynda Hariani Department of Plastic Reconstructive and Aesthetic Surgery, School of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, Indonesia Nur Febriany Nasser Department of Plastic Reconstructive and Aesthetic Surgery, School of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, Indonesia Robertus Arian Datusanantyo Department of Plastic Reconstructive and Aesthetic Surgery, School of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, Indonesia 2019 03 25 2019 05 10 Background and Objectives: Between 2007 and 2011, the mortality rate for burns patients at Dr. Soetomo General Hospital, Surabaya, Indonesia was 14.1% and 60% were suspected to be sepsis-related. Immunosuppression, gut barrier disruption, and intestinal hypomotility cause bacterial and bacterial product translocation. Probiotics improve the intestinal microbiome and eventually reduce bacterial translocation, and an increased secretory immunoglobulin A (SIgA) secretion post-administration of a multi-species probiotic has been observed. We aimed to determine whether a single-strain probiotic administration could show strengthened intestinal immunity, through an increase in SIgA levels, as with multi-strain probiotics. Materials and Methods: Sixteen burns patients from our hospital Burns Centre were randomized into three treatment groups, and the patients were administered either a placebo, a Lactobacillus reuteri protectis probiotic, or a Bifidobacterium infantis 35624 probiotic for 14 consecutive days. The SIgA levels were analyzed using ELISA pre- and post-treatment. Results: The post-treatment SIgA levels in the placebo, Lactobacillus reuteri protectis probiotic, and Bifidobacterium infantis 35624 probiotic groups were 222.56±74.22 mg/dL, 223.92±68.89 mg/dL, and 332.38±64.27 mg/dL, respectively. Decreased SIgA levels were observed in the placebo (7.19±15.87) and in the Lactobacillus reuteri protectis probiotic (1.9920±14.76) groups, whereas an increase was seen in the SIgA level in the Bifidobacterium infantis 35624 probiotic group (58.26±77.41). Conclusion: The Bifidobacterium infantis 35624 single-strain probiotic is generally superior to Lactobacillus reuteri protectis in altering intestinal immunity; however, this finding was not statistically significant. A multi-strain probiotic supplement is recommended for burns patients. https://ijm.tums.ac.ir/index.php/ijm/article/view/2074 https://ijm.tums.ac.ir/index.php/ijm/article/download/2074/1171