Tehran University of Medical Sciences Iranian Journal of Microbiology 2008-3289 7 2 2015 10 13 118 122 EN Mahshid Talebi-Taher Departments of Infectious Diseases. Ali Javadzadeh Internal Medicine and Ophthalmology. Alireza Hedayatfar Rasoul-e-Akram General Teaching Hospital, Iran University of Medical Sciences, Tehran, Iran. Shahrzad Rahmani Internal Medicine and Ophthalmology. AmirHossein Ghanooni Internal Medicine and Ophthalmology. Reihaneh Mahmoodian Internal Medicine and Ophthalmology. 2015 10 12 2015 10 12 Introduction: Frosted branch angiitis(FBA) is a panuveitis with sheating of all retinal vesssels. Case presentation: Herein we report an immunocompetent person who presented with fever, headache, atypical rash, and hazy vision. Ophthalmoscopy of both eyes revealed perivascular sheathing with frosted branch angiitis pattern in veins, patchy retinal hemorrhages. Aqueous PCR analysis turned positive for VZV. Discussion: This case illustrates that VZV should be considered in the differential diagnosis of retinal perivasculitis. Since a rapid and accurate diagnosis is crucial for prompt administration of antiviral therapy, PCR-based analysis of aqueous humor is a valuable tool for detecting viruses. https://ijm.tums.ac.ir/index.php/ijm/article/view/152 https://ijm.tums.ac.ir/index.php/ijm/article/download/152/134